NMR Spectroscopy of Glycoconjugates

Jesús Jiménez-Barbero, Thomas Peters9783527304141, 3527304142

While for many years NMR spectroscopy was one of the most useful methods of analyzing smaller molecules, nowadays it is an indispensable tool in determining the structure of complex biomolecules too. One reason for this is not least the development of increasingly powerful appliances that enabled this complicated analysis using tiny amounts of the substances in the first place. Just as the image of a 2D spectrum allows an insight into the spatial structure of a molecule, the chronological examination of an NMR experiment enables the description of the molecular dynamics. It is only by explaining such characteristics that we can really come to understand the functioning of biomolecules.This book is neither a purely analytical nor bioorganic work, and as such fills a gap for everybody working in determining the structure of carbohydrates and their conjugates. In a clearly comprehensible manner, the text summarizes the latest knowledge surrounding the use of NMR spectroscopy with such biologically important substance classes as polysaccharides, glycoproteins and glycolipides. Furthermore, it provides an insight into the interactions with other biomolecules such as proteins, nucleic acids or carbohydrates. A valuable guide for all glucochemists.