Medicinal Chemistry of Bioactive Natural Products

Xiao-Tian Liang, Wei-Shuo Fang0471660078, 9780471660071, 9780471739333

Featuring contributions by some of the worldїs leading scientists in the field, Medicinal Chemistry of Bioactive Natural Products contains articles dealing with discovery, structure elucidation, and elegant synthetic strategies developed for natural products, with an emphasis on the structure activity relationship of bioactive natural products. The topics in this book are selected carefully since bioactive natural products are clinically useful pharmaceuticals or the primary compounds under extensive medicinal chemistry exploration. The book provides examples with updated research results while also bringing a historical perspective to the chemistry and biology of some selected bioactive compounds, a technique which could inform researchers about the process of developing pharmaceuticals, from discovery to application as drugs.

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Table of contents :
Cover Page……Page 1
Title Page……Page 2
ISBN 0471660078……Page 3
1 The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors……Page 4
3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs……Page 5
4 The Overview of Studies on Huperzine A: A Natural Drugfor the Treatment of Alzheimer’s Disease……Page 6
5 Qinghaosu (Artemisinin)—A Fantastic Antimalarial Drug from a Traditional Chinese Medicine……Page 7
7 Medicinal Chemistry of Ginkgolides from Ginkgo biloba……Page 8
9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs……Page 9
Index……Page 10
PREFACE……Page 11
CONTRIBUTORS……Page 14
1 THE CHEMISTRY AND BIOLOGY OFEPOTHILONES—LEADSTRUCTURES FOR THE DISCOVERY OF IMPROVED MICROTUBULE INHIBITORS……Page 17
2 THE CHEMISTRY AND BIOLOGY OF VANCOMYCIN AND OTHER GLYCOPEPTIDE ANTIBIOTIC DERIVATIVES……Page 51
3 STRUCTURE MODIFICATIONS AND THEIR INFLUENCES ON ANTITUMOR AND OTHER RELATED ACTIVITIES OF TAXOL AND ITS ANALOGS……Page 89
4 THE OVERVIEW OF STUDIES ON HUPERZINE A: A NATURAL DRUG FOR THE TREATMENT OF ALZHEIMER’S DISEASE……Page 159
5 QINGHAOSU (ARTEMISININ)—A FANTASTIC ANTIMALARIAL DRUG FROM A TRADITIONAL CHINESE MEDICINE……Page 199
6 PROGRESS OF STUDIES ON THE NATURAL CEMBRANOIDS FROM THE SOFT CORAL SPECIES OF SARCOPHYTON GENUS……Page 273
7 MEDICINAL CHEMISTRY OF GINKGOLIDES FROM GINKGO BILOBA……Page 317
8 RECENT PROGRESS IN CALOPHYLLUM COUMARINS AS POTENT ANTI-HIV AGENTS……Page 341
9 RECENT PROGRESS AND PROSPECTS ON PLANT-DERIVED ANTI-HIV AGENTS AND ANALOGS……Page 373
10 RECENT PROGRESS ON THE CHEMICAL SYNTHESIS OF ANNONACEOUS ACETOGENINS AND THEIR STRUCTURALLY MODIFIED MIMICS……Page 415
A……Page 459
B……Page 461
C……Page 462
D……Page 464
E……Page 465
F……Page 466
H……Page 467
I……Page 468
J,K,L,M……Page 469
N……Page 470
O,P……Page 471
Q……Page 472
S……Page 473
T……Page 474
W,Y,Z……Page 476