Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications

Louis Ignarro and Ferid Murad (Eds.)978-0-12-032935-9

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. Highlights * Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide * Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases * Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction

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Table of contents :
Content:
Serial Editors
Page ii

Edited by
Page iii

Copyright page
Page iv

Contributors
Pages xix-xxiv

Chemistry of Nitric Oxide: Biologically Relevant Aspects Original Research Article
Pages 1-15
Jon M. Fukuto

Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in Vivo Original Research Article
Pages 17-43
John P. Crow, Joseph S. Beckman

Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases Original Research Article
Pages 45-69
Bruce A. Freeman, C. Roger White, Hector Gutierrez, Andrés Paler-Martínez, Margaret M. Tarpey, Homero Rubbo

Nitric Oxide Synthases: Gene Structure and Regulation Original Research Article
Pages 71-90
Yang Wang, Philip A. Marsden

Transcription of the Human Neuronal Nitric Oxide Synthase Gene in the Central Nervous System is Mediated by Multiple Promoters Original Research Article
Pages 91-112
Anthony P. Young, Ferid Murad, Harald Vaessin, Jinling Xie, Terrie K. Rife

Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase Original Research Article
Pages 113-153
Csaba Szabó, Christoph Thiemermann

Regulation and Function of Inducible Nitric Oxide Synthase during Sepsis and Acute Inflammation Original Research Article
Pages 155-170
James M. Wong, Timothy R. Billiar

Expression and Expressional Control of Nitric Oxide Synthases in Various Cell Types Original Research Article
Pages 171-186
Ulrich Förstermann, Hartmut Kleinert, Ingolf Gath, Petra Schwarz, Ellen I. Closs, Nae J. Dun

Control and Consequences of Endothelial Nitric Oxide Formation Original Research Article
Pages 187-206
Ingrid Fleming, Rudi Busse

Control of Electron Transfer in Neuronal Nitric Oxide Synthase by Calmodulin, Substrate, Substrate Analogs, and Nitric Oxide Original Research Article
Pages 207-213
Dennis J. Stuehr, Husam M. Abu-Soud, Denis L. Rousseau, Paul L. Feldman, Jianling Wang

Negative Modulation of Nitric Oxide Synthase by Nitric Oxide and Nitroso Compounds Original Research Article
Pages 215-234
Jeanette M. Griscavage, Adrian J. Hobbs, Louis J. Ignarro

Regulation of Nitric Oxide Synthase: Role of Oxygen Radicals and Cations in Nitric Oxide Formation Original Research Article
Pages 235-250
Chandra K. Mittal, Chander S. Mehta

Why Tetrahydrobiopterin? Original Research Article
Pages 251-261
Bernd Mayer, Ernst R. Werner

Nitric Oxide and cGMP Signaling Original Research Article
Pages 263-275
Lee J. McDonald, Ferid Murad

Nitric Oxide and Intracellular Heme Original Research Article
Pages 277-291
Young-Myeong Kim, Hector A. Bergonia, Claudia Müller, Bruce R. Pitt, W. David Watkins, Jack R. Lancaster Jr.

High-Level Expression of Biologically Active Soluble Guanylate Cyclase Using the Baculovirus System is Strongly Heme-Dependent Original Research Article
Pages 293-303
Wolfgang A. Buechler, Sujay Singh, Janet Aktas, Stefan Müller, Ferid Murad, Rupert Gerzer

cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases Original Research Article
Pages 305-322
Thomas M. Lincoln, Padmini Komalavilas, Nancy J. Boerth, Lee Ann MacMillan-Crow, Trudy L. Cornwell

Physiological and Toxicological Actions of Nitric Oxide in the Central Nervous System Original Research Article
Pages 323-342
Valina L. Dawson, Ted M. Dawson

S-Nitrosothiols: Chemistry, Biochemistry, and Biological Actions Original Research Article
Pages 343-349
Gilbert R. Upchurch Jr., George N. Welch, Joseph Loscalzo

Glyceraldehyde-3-phosphate Dehydrogenase: A Target for Nitric Oxide Signaling Original Research Article
Pages 351-360
Bernhard Brüne, Eduardo G. Lapetina

Nitric Oxide Donors: Biochemical Pharmacology and Therapeutics Original Research Article
Pages 361-381
John Anthony Bauer, Brian P. Booth, Ho-Leung Fung

Nitric Oxide Donors: A Continuing Opportunity in Drug Design Original Research Article
Pages 383-398
Stephen R. Hanson, Thomas C. Hutsell, Larry K. Keefer, Daniel L. Mooradian, Daniel J. Smith

Nitric Oxide and Peripheral Adrenergic Neuromodulation Original Research Article
Pages 399-413
Roberto Levi, Kwan Ha Park, Michiaki Imamura, Nahid Seyedi, Harry M. Lander

A Study on Tumor Necrosis Factor, Tumor Necrosis Factor Receptors, and Nitric Oxide in Human Fetal Glial Cultures Original Research Article
Pages 415-438
Barbara A. St. Pierre, Douglas A. Granger, Joyce L. Wong, Jean E. Merrill

Inhaled Nitric Oxide, Clinical Rationale and Applications Original Research Article
Pages 439-456
Claes G. Frostell, Warren M. Zapol

Inhaled Nitric Oxide Therapy of Pulmonary Hypertension and Respiratory Failure in Premature and Term Neonates Original Research Article
Pages 457-474
Steven H. Abman, John P. Kinsella

Clinical Applications of Inhaled Nitric Oxide in Children with Pulmonary Hypertension Original Research Article
Pages 475-504
David L. Wessel, Ian Adatia

Index
Pages 505-516