Adenosine receptors in health and disease

Kenneth A. Jacobson (auth.), Constance N. Wilson, S. Jamal Mustafa (eds.)9783540896159, 3540896155

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Table of contents :
Front Matter….Pages i-xiii
Introduction to Adenosine Receptors as Therapeutic Targets….Pages 1-24
A 1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers….Pages 25-58
Recent Developments in Adenosine A 2A Receptor Ligands….Pages 59-98
Recent Developments in A 2B Adenosine Receptor Ligands….Pages 99-122
Medicinal Chemistry of the A 3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering….Pages 123-159
Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology….Pages 161-188
Adenosine Receptors and Reperfusion Injury of the Heart….Pages 189-214
Adenosine Receptors and Inflammation….Pages 215-269
A 1 Adenosine Receptor: Role in Diabetes and Obesity….Pages 271-295
A 3 Adenosine Receptor: Pharmacology and Role in Disease….Pages 297-327
Adenosine Receptors and Asthma….Pages 329-362
Adenosine Receptors, Cystic Fibrosis, and Airway Hydration….Pages 363-381
Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis….Pages 383-397
Adenosine Receptors and Cancer….Pages 399-441
Adenosine Receptors and the Kidney….Pages 443-470
Adenosine Receptors and the Central Nervous System….Pages 471-534
Adenosine Receptors and Neurological Disease: Neuroprotection and Neurodegeneration….Pages 535-587
Adenosine A 2A Receptors and Parkinson’s Disease….Pages 589-615
Adenosine Receptor Ligands and PET Imaging of the CNS….Pages 617-642
Back Matter….Pages 643-652