Antisense Drug Technology: Principles, Strategies and Applications

Stanley T. Crooke9780849387968, 0849387965

Offering contributions from over 60 experts, this volume provides comprehensive coverage of the development of antisense oligonucleotides and showcases the benefits of antisense drugs-including reduced toxicity and earlier disease detection-useful for treating cancer, as well as infectious, inflammatory, and immune-mediated diseases. It presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes, and highlights advances in chemistry, RNA biochemistry, and molecular and cellular biology leading to new therapeutic compounds. The text is augmented with numerous tables, illustrations, and a wealth references.