Encyclopedia of Physical Science and Technology – Molecular Biology

Robert A. Meyers (Editor)978-0122274107

Table of contents :
Cover Page……Page 1
Table of Contents……Page 2
Glossary……Page 3
Overview……Page 4
Death Factors and Their Receptors……Page 5
Signal Transduction of Death Factor-Mediated Apoptosis……Page 6
Cell-Free System in Apoptosis……Page 10
Apoptotic DNase, CAD and Its Inhibitor, ICAD……Page 11
Molecular Mechanism of CAD and ICAD……Page 12
Physiological DNA Fragmentation and Phagocytosis of Apoptotic Cells……Page 14
References……Page 16
Glossary……Page 17
The 6-Billion Challenge……Page 18
Chromatin: A Brief History of Scholarship……Page 19
The Histones……Page 20
Experimental Evidence for the Histones’ Role in Controlling Gene Expression……Page 21
Ontology of the Nucleosome……Page 22
DNA Structure in the Nucleosome……Page 23
The Histone Octamer……Page 24
The Disruption and Modification of Chromatin Structure as a Tool to Control the Genome……Page 27
Remodeling……Page 28
Modification……Page 29
Disrupt and Conquer: ATP-Dependent Chromatin Remodeling Engines……Page 31
The Power of Amendments:……Page 34
Chromatin and Transcription: A Synthesis……Page 36
References……Page 37
Glossary……Page 38
Where is DNA Found?……Page 40
Destruction of DNA……Page 41
Nonorganic Extraction……Page 43
Slot-Blot Quantitation……Page 44
Definition and Description of PCR……Page 45
Detection of PCR Products……Page 46
Fluorescent Dyes……Page 47
Fluorescent Detection Equipment……Page 48
STR Detection……Page 49
References……Page 50
Glossary……Page 52
Definition of a Transcription Unit……Page 53
Upstream Regulatory Factors……Page 54
Regulation of Promoter Activity……Page 55
Regulation of Transcription by Chromatin Remodeling……Page 56
Regulation of Transcription Factor Activity……Page 57
Introduction……Page 58
Posttranscriptional Regulation of Gene Expression……Page 59
Mechanism of RNA Splice Site Choice During Spliceosome Assembly……Page 60
Alternative RNA Splicing is an Important Mechanism to Generate Protein Diversity……Page 62
Regulation of Alternative RNA Splicing by Changes in SR Protein Activity……Page 63
Introduction……Page 64
Regulation of Gene Expression at the Level of Alternative Poly(A) Site Usage……Page 65
Transcription and RNA Processing Are Coordinately Regulated Events……Page 66
References……Page 67
Glossary……Page 68
Autoimmunity and Autoantibodies……Page 69
History……Page 73
Addition of primary antibody……Page 74
History……Page 75
Principle……Page 76
Method……Page 77
History……Page 78
Perspectives……Page 79
References……Page 80
Introduction……Page 81
Group II Introns……Page 82
Hammerhead Ribozymes……Page 83
Ribozyme Delivery……Page 84
Ribozyme Applications……Page 85
Functional Genomics and Target Validation……Page 86
Ribozyme Mediated RNA Repair……Page 87
Ribozyme Evolution……Page 88
References……Page 89
Glossary……Page 90
Structure……Page 91
Eukaryotic mRNA……Page 93
Transfer Rna……Page 94
Prokaryotic systems……Page 96
Eukaryotic systems……Page 98
Elongation……Page 101
Translocation……Page 102
High-Resolution Structural Studies of the Ribosome……Page 103
mRNA Stability……Page 104
Control by mRNA Structure……Page 106
Modulation of Ribosome Activity……Page 108
References……Page 109