Neoplastic diseases of the blood

Peter H. Wiernik, John M. Goldman, Janice P. Dutcher, Robert A. Kyle0521791367, 9780521791366

In this fourth edition of the classic work on malignant blood cancers, the team of editors and over 100 international leaders in the field provide a comprehensive text on the diagnosis and treatment of all hematologic malignancies, both common and rare. This extensively revised and updated edition reflects the tremendous progress in the science and treatment of hematologic malignancies during the eight years since the third edition. Revisions and new chapters include coverage of stem cell transplantation, molecular genetics, monoclonal antibodies, and new treatment modalities.

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Table of contents :
Front……Page 1
Contents……Page 9
Contributors……Page 13
Preface……Page 19
SECTION ONE – Chronic Leukemias and Related Disorders……Page 21
1: A History of the Chronic Leukemias……Page 23
2: Epidemiology of the Chronic Leukemias……Page 29
3: Pathology and Morphology of Chronic Leukemias and Related Disorders……Page 36
4: Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia……Page 56
5: Diagnosis and Treatment of Chronic Myeloid Leukemia……Page 73
6: Molecular Biology and Cytogenetics of Chronic Lymphocytic Leukemia……Page 90
7: Diagnosis and Treatment of Chronic Lymphocytic Leukemia……Page 103
8: Diagnosis and Treatment of Hairy Cell Leukemia……Page 116
9: The Pathogenesis, Diagnosis, and Treatment of Polycythemia Vera……Page 131
10: The Diagnosis and Treatment of Essential Thrombocythemia and Chronic Idiopathic Myelofibrosis……Page 145
SECTION TWO – Acute Leukemias……Page 153
11: Historical Perspectives on Acute Leukemias……Page 155
12: Human T-Cell Lymphoma/Leukemia Virus – Associated T-Cell Lymphoma and Leukemia……Page 161
13: Epidemiology and Hereditary Aspects of Acute Leukemia……Page 184
14: Classification of the Acute Leukemias: Cytochemical and Morphological Considerations……Page 196
15: Immunobiology of Acute Leukemia……Page 214
16: Cytogenetics of Acute Leukemia……Page 252
17: Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia……Page 269
18: Diagnosis and Treatment of Adult Acute Lymphoblastic Leukemia……Page 293
19: Diagnosis and Treatment of Childhood Acute Myelogenous Leukemia……Page 326
20: Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other Than Acute Promyelocytic Leukemia……Page 336
21: Acute Promyelocytic Leukemia……Page 356
22: Therapy-Related Acute Myelogenous Leukemia……Page 390
23: Myelodysplastic Syndromes……Page 415
SECTION THREE – Myeloma and Related Disorders……Page 433
24: History of Multiple Myeloma……Page 435
25: Cytokines and Signal Transduction in Multiple Myeloma……Page 444
26: Epidemiology of Multiple Myeloma……Page 454
27: Immunoglobulins and Laboratory Recognition of Monoclonal Proteins……Page 466
28: Cytogenetic Abnormalities in the Monoclonal Gammopathies……Page 490
29: Molecular Genetics in Multiple Myeloma and Related Disorders……Page 497
30: Staging, Kinetics, and Prognosis in Multiple Myeloma……Page 508
31: Diagnosis and Treatment of Multiple Myeloma……Page 547
32: Syndromes and Special Presentations Associated with Plasma Cell Myeloma……Page 567
33: Waldenström’s Macroglobulinemia……Page 582
34: Heavy-Chain Disease……Page 593
35: Amyloidosis (AL)……Page 615
36: Monoclonal Gammopathies of Undetermined Significance……Page 639
SECTION FOUR – Lymphoma……Page 669
37: Historical Overview of Malignant Lymphoma……Page 671
38: Genetic Factors in Lymphomagenesis……Page 682
39: Epidemiology and Hereditary Aspects of Malignant Lymphoma and Hodgkin’s Disease……Page 693
40: Pathology of Non-Hodgkin’s Lymphomas and Hodgkin’s Disease……Page 707
41: Immunology of the Lymphomas……Page 754
42: Cytogenetics of Non-Hodgkin’s Lymphoma and Hodgkin’s Disease……Page 786
43: Diagnosis and Treatment of Hodgkin’s Disease……Page 816
44: Radiotherapeutic Management of Lymphomas……Page 838
45: Diagnosis and Treatment of Non-Hodgkin’s Lymphoma of Adults……Page 847
46: Non-Hodgkin’s Lymphoma of Childhood……Page 863
47: Lymphoma in Other Diseases……Page 882
SECTION FIVE – Supportive Care……Page 939
48: Historical Perspectives in Supportive Care……Page 941
49: Prevention of Infections in Patients With Hematological Malignancies……Page 946
50: Evaluation and Management of Bacterial and Fungal Infections Occurring in Patients With a Hematological Malignancy……Page 975
51: Viral Infections in Patients with Hematological Malignancies……Page 988
52: Therapeutic Cytapheresis and Plasma Exchange……Page 1026
53: Red Cell Transfusions in Patients with Hematologic Malignancies……Page 1037
54: Platelet and Granulocyte Transfusion……Page 1048
55: Stem Cell Processing and Purging……Page 1069
56: Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications……Page 1084
57: Umbilical Cord Blood Banking and Transplantation……Page 1099
58: HLA Typing in Hematopoietic Cell Transplantation……Page 1105
59: Special Care of Blood and Marrow Stem Cell Transplant Patients……Page 1116
60: Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Malignancies……Page 1143
61: Bleeding and Thrombosis in Hematologic Neoplasia……Page 1157
62: Psychological Aspects of Hematological Malignancies……Page 1175
Index……Page 1187