Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling

Joachim K. Seydel, Michael Wiese, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers9783527304271, 3-527-30427-4

Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today’s pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors’ long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

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Table of contents :
Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling (2002)……Page 1
1. Function, Composition, and Organization of Membranes……Page 22
2. Octanol–Water Partitioning versus Partitioning into Membranes……Page 55
3. Analytical Tools for the Analysis and Quantification of Drug–Membrane
Interactions……Page 71
4. Drug–Membrane Interaction and Pharmacokinetics of Drugs……Page 161
5. Drug–Membrane Interactions and Pharmacodynamics……Page 237
6. Computer Simulation of Phospholipids and Drug–Phospholipid
Interactions……Page 311