The serotonin receptors: from molecular pharmacology to human therapeutics

Bryan L. Roth9781588295682, 1-58829-568-0

Content: Molecular biology and genomic organization of G protein-coupled serotonin receptors — Structure and function reveal insights in the pharmacology of 5-HT receptor subtypes — Polymorphic and posttranscriptional modifications of 5-HT receptor structure: functional and pathological implications — Strategies for the development of selective serotonergic agents — 5-HT receptor signal transduction pathways — Agonist-directed trafficking of 5-HT receptor-mediated signal transduction — Identification of 5-HT2 and 5-HT4 receptor-interacting proteins: a proteomic approach — 5-HT receptor-associated proteins (FRAPs): relevance for targeting, trafficking, and signal transduction — Cellular and subcellular localization of serotonin receptors in the central nervous system — Chemical neuroanatomy of 5-HT receptor subtypes in the mammalian brain — Modulation of the neuronal activity and neurotransmitter release by 5-HT1A and 5-HT1B/1D receptors — Electrophysiology of 5-HT2A receptors and relevance for hallucinogen and atypical antipsychotic drug actions — The emergence of 5-HT2B receptors as targets to avoid in designing and refining pharmaceuticals — The 5-HT3 receptor — 5-HT3 and 5-HT4 receptors as targets for drug discovery for dementia — Electrophysiological properties of Gas-coupled 5-HT receptors (5-HT4, 5-HT6, 5-HT7) — 5-HT6 receptors as targets for the treatment of cognitive deficits in schizophrenia — 5-HT7 receptors as favorable pharmacological targets for drug discovery — Serotonin system gene knockouts: a story of mice with implications for man — Effects of serotonin-related gene deletion on measures of anxiety, depression, and neurotransmission