mateo protein-lipid interactions-new approaches and emerging concepts

C.Reyes Mateo, Javier Gómez, José Villalaín, José Manuel González Ros3-540-28400-1, 978-3-540-28400-0

Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of protein–lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.

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Table of contents :
Front……Page 1
Preface……Page 4
Contents……Page 5
List of contributors……Page 10
1: From lipid phases to membrane protein organization: fluorescence methodologies in the study of lipid-protein interactions……Page 12
2: NMR of membrane proteins in lipid environments: the Bcl-2 family of apoptosis regulators……Page 45
3: X-ray and neutron diffraction approaches to the structural analysis of protein-lipid interactions……Page 72
4: The role of proteins in the formation of domains in membranes……Page 120
5: Lateral membrane strucutre and lipid-protein interactions……Page 136
6: The membrane as a system: how lipid structure affects membrane protein function……Page 150
7: Peptide-lipid interaction: shedding light into the mode of action and cell specificity of antimicrobial peptides……Page 185
8: Structural and functional modulation of ion channels by specific lipids: from model systems to cell membranes……Page 210
Subject index……Page 239