Signaling Networks and Cell Cycle Control

J. Silvio Gutkind9780896037106, 089603710X

In recent years, following an explosion in the knowledge of how cell surface receptors transmit signals to the nucleus, it has been uncovered that a unique group of signaling molecules link each class of receptors to a variety of newly discovered kinase cascades. This recent identification of key signaling and cell-regulating molecules has provided a golden opportunity in the search for novel targets for therapeutic intervention in disease. Signal Transduction and Cell Cycle Inhibitors describes up-to-date knowledge on signaling pathways and cell cycle control, as well as the efforts of several groups to design, synthesize, and evaluate the biochemical and biological activities of inhibiting molecules. The contributors are leading scientists in the field who emphasize the areas that are still open for exploration and attempt to define the most likely targets for pharmacological intervention. This is a comprehensive review of the most current information regarding biologically relevant cell surface receptors, which is invaluable for understanding the emerging principles in the field. It will serve as a guiding tool for those involved in basic research, as well as for those who are more experienced and actively engaged in drug discovery efforts.