Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Ragu Ramanathan0471751588, 978-0-471-75158-8

Evolving role of mass spectrometry in drug discovery and development / Dil M. Ramanathan and Richard M. LeLacheur — Quantitative bioanalysis in drug discovery and development: principles and applications / Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen — Quadrupole, triple-quadrupole, and hybrid linear ion trap mass spectrometers in metabolite analysis / Elliott B. Jones — Applications of quadrupole time-of-flight mass spectrometry in reactive metabolite screening / Jose M. Castro-Perez — Changing role of FTMS in drug metabolism / Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders — High-resolution LC-MS based mass defect filter approach: basic concept and application in metabolite detection / Haiying Zhang … [et al.]., Applications of high-sensitivity mass spectrometry and radioactivity detection techniques in drug metabolism studies / Wing W. Lam … [et al.] — Online electrochemical-LC-MS techniques for profiling and characterizing metabolites and degradants / Paul H. Gamache … [et al.] — LC-MS methods with hydrogen/deuterium exchange for identification of hydroxylamine, n-oxide, and hydroxylated analogs of desloratadine / Natalia A. Penner … [et al.] — Turbulent-flow LC-MS: applications for accelerating pharmacokinetic profiling and metabolite identification / Joseph L. Herman and Joseph M. Di Bussolo — Desorption ionization techniques for quantitative analysis of drug molecules / Jason S. Gobey, John Janiszewski, and Mark J. Cole — MALDI imaging mass spectrometry for direct tissue analysis of pharmaceuticals / Yunsheng Hsieh and Walter A. Korfmacher