Free-radical-induced DNA damage and its repair: a chemical perspective

Clemens von Sonntag3540261206, 9783540261209

Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.

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Table of contents :
Cover……Page 1
Half-Title……Page 2
Inside Cover……Page 3
Copyright……Page 4
Preface……Page 5
Contents……Page 7
Abbreviations……Page 15
1. Introduction……Page 21
2. Formation of Reactive Free Radicals in an Aqueous Environment……Page 25
3. The Hydroxyl Radical……Page 64
4. Hydrogen Atom and Hydrated Electron……Page 92
5. Inorganic Radicals……Page 101
6. Carbon-Centered Radicals……Page 113
7. Heteroatom-Centered Radicals……Page 146
8. Peroxyl Radicals……Page 169
9. Polymer Radicals……Page 204
10. Nucleobases, Nucleosides and Nucleotides……Page 219
11. Polynucleotides and Single-Stranded DNA Fragments……Page 343
12. DNA and Double-Stranded Oligonucleotides……Page 363
13. Methods……Page 489
Subject Index……Page 510