Cardiovascular Genetics and Genomics for the Cardiologist

Victor J. Dzau MD, Choong-Chin Liew PhD1-4051-3394-5, 978-1-4051-3394-4

Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.
In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand: • how cardiovascular genetics may remodel the way cardiovascular medicine is practiced • what material has immediate relevance to the practicing clinician • how to incorporate genetics and genomics in your practice to ensure up-to-date patient care
The book opens with introductory chapters, then discusses: • cardiovascular single gene disorders • cardiovascular polygenic disorders • therapies and applications
Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

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Table of contents :
Contributors……Page 6
Foreword……Page 8
CHAPTER 1 The gene in the twenty-first century……Page 14
PART I Cardiovascular single gene disorders……Page 30
CHAPTER 2 Monogenic hypercholesterolemia……Page 32
CHAPTER 3 Hypertrophic cardiomyopathy……Page 43
CHAPTER 4 Dilated cardiomyopathy and other cardiomyopathies……Page 68
CHAPTER 5 The long QT syndrome……Page 96
PART II Cardiovascular polygenic disorders……Page 124
CHAPTER 6 Atherosclerosis……Page 126
CHAPTER 7 Heart failure……Page 150
CHAPTER 8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension……Page 179
PART III Therapies and applications……Page 206
CHAPTER 9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects……Page 208
CHAPTER 10 Stem cell therapy for cardiovascular disease……Page 238
CHAPTER 11 Pharmacogenetics and personalized medicine……Page 263
CHAPTER 12 The potential of blood-based gene profiling for disease assessment……Page 290
Index……Page 314