Male-mediated Developmental Toxicity Issues in Toxicology

Diana Anderson, Martin H. Brinkworth0854048472, 978-0-85404-847-2

Table of contents :
Cover……Page 1
Male-mediated Developmental Toxicity……Page 2
Series Title……Page 3
Title……Page 4
Copyright……Page 5
Foreword……Page 6
Preface……Page 10
Contents……Page 12
Dedication……Page 22
Acknowledgements……Page 23
Introductory Scientific Presentations……Page 24
1 Epigenetic Transgenerational Actions of Endocrine Disruptors through the Male Germ-Line……Page 26
Heritable Effects in Humans……Page 30
2 Reproductive Outcomes among Men Treated for Cancer……Page 32
3 Cancer in Siblings of Children with Cancer in the Nordic Countries: A Population-Based Cohort Study Paediatric Cancer: An Indicator of Familial Cancer Risk?……Page 40
4 What Harms the Developing Male Reproductive System?……Page 53
5 Links between Paternal Smoking and Childhood Cancer……Page 76
6 Feasibility Study of Metal Effects on the X:Y Ratio in Human Sperm……Page 86
7 Use of the Sperm Chromatin Structure Assay (SCSA®) as a Diagnostic Tool in the Human Infertility Clinic……Page 102
8 Safety of Sperm for Use in Intra-Cytoplasmic Sperm Injection……Page 110
Animal Models……Page 120
9 Male-Mediated F1 Effects in Mice Exposed to Di(2-ethylhexyl)phthalate (DEHP)……Page 122
10 Prevention of Adverse Effects of Cancer Treatment of Germline……Page 139
11 Molecular Changes in Sperm and Early Embryos after Paternal Exposure to a Chemotherapeutic Agent……Page 149
12 Transmissible Genetic Risk Causing Tumours in Mice and Humans……Page 159
13 Heritable Effects on DNA Damage Following Paternal F0 Germline Irradiation……Page 174
14 Influence of DNA Methylation and Genomic Imprinting in the Male Germ Line on Pregnancy Outcome……Page 190
15 Information Content of Ejaculate Spermatozoa and its Potential Utility in Toxicology and Infertility Based Research Programmes……Page 201
Germline Mutagenesis……Page 214
16 Origin of Paternal Mutations……Page 216
17 Redox Regulation of DNA Damage in the Male Germ Line……Page 222
18 Advances in the Direct Measurements of Partial Chromosomal Duplication, Deletions and Breaks in Human and Murine Sperm by Sperm FISH……Page 235
19 Radiation-induced Transgenerational Instability in Mice……Page 249
20 New Genetic Information Generated by Endogenous Reverse Transcription in Sperm Cells……Page 260
21 Sperm Abnormalities in Exposed Humans……Page 272
22 Oestrogenic Compounds and Oxidative Stress……Page 284
23 DNA Repair Capacities in Testicular Cells of Rodents and Man……Page 298
24 3rd International Congress on Male-Mediated Developmental Toxicity: Closing Panel Discussion……Page 311
Subject Index……Page 314