Base Excision Repair

Kivie Moldave, Sankar Mitra, Amanda K. McCullough, R. Stephen Lloyd, Samuel H. Wilson (Eds.)0125400683, 9780125400688

This volume of Progress in Nucleic Acid Research and Molecular Biology represents research discussed during the DNA Base Excision Repair Workshop. This compilation of articles focuses on several recent observations highlighting the complexity of the base excision repair (BER) process in DNA repair. Focusing on the various facets of BER research, this book is a timely and highly beneficial reference for investigators in the DNA repair field. It will also aid scientists not directly involved in repair studies to obtain a comprehensive understanding of the current state of knowledge in the field.

---

Table of contents :
Content:
Preface
Pages xv-xvi
Sankar Mitra, R Stephen Lloyd, Priscilla K Cooper, Samuel H Wilson

Keynote: Past, present, and future aspects of base excision repair Review Article
Pages xvii-xxx
Thomas Lindahl

Session 1 multiple pathways for DNA base excision repair
Page 1
Eugenia Dogliotti

The mechanism of switching among multiple BER pathways Original Research Article
Pages 3-27
Eugenia Dogliotti, Paola Fortini, Barbara Pascucci, Eleonora Parlanti

Yeast base excision repair: Interconnections and networks Review Article
Pages 29-39
Paul W Doetsch, Natalie J Morey, Rebecca L Swanson, Sue Jinks-Robertson

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis Review Article
Pages 41-54
Bernd Kaina, Kirsten Ochs, Sabine Grösch, Gerhard Frizz, Jochen Lips, Maja Tomicic, Torsten Dunkern, Markus Christmann

Session 2 gene targeting in the mouse for elucidating the role of BER
Page 55
Samuel H Wilson

Mammalian DNA β-polymerase in base excision repair of alkylation damage Review Article
Pages 57-74
Robert W Sobol, Samuel H Wilson

Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage Review Article
Pages 75-94
Yusaku Nakabeppu

Repair of 8-oxoguanine and oggl-incised apurinic sites in a CHO cell line Review Article
Pages 95-105
Serge Boiteux, Florence Le Page

Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA Review Article
Pages 107-123
Susumu Nishimura

Session 3 Complexities of BER
Pages 125-127
Michael Weinfeld

Molecular mechanism of PCNA-dependent base excision repair Review Article
Pages 129-138
Yoshihiro Matsumoto

Factors influencing the removal of thymine glycol from DNA in γ-irradiated human cells Review Article
Pages 139-149
Michael Weinfeld, James Z Xing, Jane Lee, Steven A Leadon, Priscilla K Cooper, X.Chris Le

Completion of base excision repair by mammalian DNA ligases Review Article
Pages 151-164
Alan E Tomkinson, Ling Chen, Zhiwan Dong, John B Leppard, David S Levin, Zachary B Mackey, Teresa A Motycka

Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma loVo and Escherichia coli cell extracts Review Article
Pages 165-188
Russell J Sanderson, Samuel E Bennett, Jung-Suk Sung, Dale W Mosbaugh

Session 4 DNA glycosylases: Specificity and mechanisms
Pages 189-192
Sankar Mitra

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in Vivo functions Review Article
Pages 193-205
Tapas K Hazra, Jeff W Hill, Tadahide Izumi, Sankar Mitra

DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes Review Article
Pages 207-221
Hiroshi Ide

Mechanism of action of Escherichia coli formamidopyrimidine N-glycosylase: Role of K155 in substrate binding and product release Review Article
Pages 223-234
Lois Rabow, Radhika Venkataraman, Yoke W Kow

Thymine DNA glycosylase Review Article
Pages 235-253
Ulrike Hardeland, Marl Bentele, Teresa Lettieri, Roland Steinacher, Josef Jiricny, Primo Schär

Session 5 Mitochondrial DNA repair
Pages 255-256
Vilhelm A Bohr

Enzymology of mitochondrial base excision repair Review Article
Pages 257-271
Daniel F Bogenhagen, Kevin G Pinz, Romina M Perez-Jannotti

Base excision repair of mitochondrial DNA damage in mammalian cells Review Article
Pages 273-284
S.P Ledoux, G.L Wilson

Base excision repair in nuclear and mitochondrial DNA Review Article
Pages 285-297
Grigory L Dianov, Nadja Souza-Pinto, Simon G Nyaga, Tanja Thybo, Tinna Stevnsner, Vilhelm A Bohr

Session 6 structural implications of BER enzymes: Dragons dancing—The structural biology of DNA base excision repair
Pages 299-304
John A Tainer

Crystallizing thoughts about DNA base excision repair Review Article
Pages 305-314
Thomas Hollis, Albert Lau, Tom Ellenberger

DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes Review Article
Pages 315-347
David J Hosfield, Douglas S Daniels, Clifford D Mol, Christopher D Putnam, Sudip S Parikh, John A Tainer

Potential double-flipping mechanism by E. coli MutY Review Article
Pages 349-364
Paul G House, David E Volk, Varatharasa Thiviyanathan, Raymond C Manuel, Bruce A Luxon, David G Gorenstein, R Stephen Lloyd

Properties and functions of human uracil-DNA glycosylase from the UNG gene Review Article
Pages 365-386
Hans E Krokan, Marit Otterlei, Hilde Nilsen, Bodil Kavli, Frank Skorpen, Sonja Andersen, Camilla Skjelbred, Mansour Akbari, Per Arne Aas, Geir Slupphaug

Index
Pages 387-403