Phencyclidine: An update

Doris H. Clouet

Table of contents :
Table of Contents……Page 12
Foreword……Page 6
Preface……Page 8
Characterization of Phencyclidine and Sigma Receptor-Binding Sites in Brain……Page 14
Further Evidence of Phencyclidine/Sigma Opioid Receptor Commonality……Page 27
Isolation and Identification of an Endogenous Ligand for the Phencyclidine Receptor……Page 37
Phencyclidine (PCP) Selectively Blocks Certain Presynapt Potassium Channels……Page 50
Involvement of Dopaminergic, Cholinergic, and Glutamatergic Mechanisms in the Actions of Phencyclidine-Like Drugs……Page 65
Anticonvulsant Properties of Phencyclidine and Ketamine……Page 80
Agonistic and Antagonistic Effects of PCP-Derivatives and Sigma Opioids in PCP Behavioral and Receptor Assays……Page 93
Electroencephalographic (EEG), Psychopharmacological, and Receptor-Binding Profiles of ‘Phencyclinoids’……Page 107
Modulation of Phencyclidine (PCP) Pharmacokinetics With PCP-Specific Fab Fragments……Page 125
Psychopharmacology of Phencyclidine……Page 140
Discriminative Stimulus Properties of PCP Mimetics……Page 147
Clinical Implications of Behavioral Pharmacology Research on Phencyclidine……Page 161
Phencyclidine: Changing Abuse Patterns……Page 176
PCP and Crime: Just Another Illicit Drug?……Page 187
Neuropsychological Assessment of Phencyclidine Abusers……Page 203
Phencyclidine Intoxication……Page 222
Diagnosis and Treatment of Chronic Phencyclidine (PCP) Abuse……Page 231
Legal Issues Associated With PCP Abuse–The Role of the Forensic Expert……Page 242
The Long-Term Effects on Neurodevelopment in Infants Exposed Prenatally to PCP……Page 250
Clinical Observations in the Treatment of Adolescent and Young Adult PCP Abusers……Page 265
List of NIDA Research Monographs……Page 274