Enzyme Systems that Metabolise Drugs and Other Xenobiotics

Costas Ioannides9780471894667, 0-471-89466-4

This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include: enzyme function in the metabolism and bioactivation of xenobiotics substrate specificity tissue distribution species distribution (to include laboratory animals and humans) hormonal regulation sex differences modulation by prior exposure to other chemicals age-dependent expression pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.

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Table of contents :
Cover Page……Page 1
Current Toxicology Series……Page 3
Title Page……Page 4
Edition Info……Page 5
Contents……Page 6
Contributors……Page 8
Foreword……Page 10
1 Xenobiotic Metabolism: An Overview……Page 11
2 Cytochrome P450……Page 43
3 Flavin Monooxygenases……Page 77
4 Amine Oxidases and the Metabolism of Xenobiotics……Page 105
5 Molybdenum Hydroxylases……Page 157
6 Prostaglandin Synthases……Page 199
7 Lipoxygenases……Page 241
8 UDP-Glucuronosyltransferases……Page 291
9 Glutathione S-transferases……Page 329
10 Sulphotransferases……Page 363
11 Arylamine Acetyltransferases……Page 451
12 Mammalian Xenobiotic Epoxide Hydrolases……Page 469
13 Methyltransferases……Page 495
14 The Amino Acid Conjugations……Page 511
15 Deconjugating Enzymes; Sulphatases and Glucuronidases……Page 531
16 Nitroreductases and Azoreductases……Page 565
Index……Page 577
Back Page……Page 589