The practical bioinformatician

Limsoon Wong9789812388469, 9789812562340, 981238846X, 9812566651, 9789812566652

Computer scientists have increasingly been enlisted as “bioinformaticians” to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics:
? Overview of modern molecular biology and a broad spectrum of techniques from computer science — data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc. ? In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences. ? Incisive discussion of computational prediction of secondary structure of RNA sequences. ? Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function. ? Overview of methods for discovering protein–protein interactions. ? Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions. ? Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.