Supercritical Fluid Technology for Drug Product Development

Peter York, Uday B. Kompella, Boris Y. Shekunov0824748050, 9780824748050, 9780824751029

Primarily intended for pharmaceutical scientists and graduate students, this collection brings together the fundamentals, process engineering, and pharmaceutical applications of supercritical fluid technologies. The 15 chapters describe the preparation of particulate drug and drug delivery systems and present developments that will either directly or indirectly impact the future of pharmaceutical products, such as supercritical fluid chromatography and the scale-up of supercritical fluid processes for nutraceuticals. Other topics include colloid and interfacial phenomenon for carbon dioxide-based systems, control of the drug physical form, supercritical fluid impregnation of polymers for drug delivery, and the effect of supercritical fluids on proteins during processing.