Pediatric Epilepsy-Diagnosis and Therapy

John M., M.D. Pellock, Edwin W., M.D. Dodson, Blaise F. D., M.D. Bourgeois, Douglas R., Jr, M.d. Nordlii, Raman Sankar1-933864-16-8, 978-1-933864-16-7

The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies.
Written by nearly 100 international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology, etiology, diagnosis, and age-related syndromes of epilepsy. The core of the new third edition is its completely updated section on antiepileptic drugs, including an in-depth discussion of dosage considerations, drug toxicity, teratogenicity, and drug interactions, with recommendations for optimal combinations when multiple drug therapy is required.

---

Table of contents :
Cover……Page 1
Title Page……Page 3
Contents……Page 9
Preface……Page 15
Contributors……Page 17
1. Pathophysiology of Seizures and Epilepsy in the Immature Brain: Cells, Synapses, and Circuits……Page 27
2. Ion Channels, Membranes, and Molecules in Epilepsy and Neuronal Excitability……Page 55
3. Channel Mutations in Epilepsy: A Neurodevelopmental Perspective……Page 71
4. Metabolic and Pharmacologic Consequences of Seizures……Page 89
5. Neuropathologic Substrates of Epilepsy……Page 99
6. Epileptogenic Cerebral Cortical Malformations……Page 125
7. Genetic Influences on the Risk for Epilepsy……Page 141
8. Classification of Epilepsies in Childhood……Page 161
9. Epidemiology of Epilepsy in Children……Page 171
10. An Approach to the Child with Paroxysmal Phenomena with Emphasis on Nonepileptic Disorders……Page 189
11. Evaluating the Child with Seizure……Page 209
12. The Use of Electroencephalography in the Diagnosis of Epilepsy in Childhood……Page 219
13. Basics of Neuroimaging in Pediatric Epilepsy……Page 237
14. Neonatal Seizures……Page 253
15. Severe Encephalopathic Epilepsy in Early Infancy……Page 265
16. Severe Encephalopathic Epilepsy in Infants: Infantile Spasms (West Syndrome)……Page 273
17. Myoclonic Epilepsies in Infancy and Early Childhood……Page 293
18. Partial Epilepsies in Infancy……Page 307
19. Febrile Seizures……Page 317
20. Generalized Epilepsy with Febrile Seizures Plus (GEFS )……Page 327
21. Lennox-Gastaut Syndrome……Page 331
22. Childhood Absence Epilepsies……Page 347
23. Benign Focal Epilepsies of Childhood……Page 359
24. The Landau-Kleffner Syndrome and Epilepsy with Continuous Spike-Waves during Sleep……Page 375
25. Idiopathic Generalized Epilepsy of Adolescence……Page 383
26. Progressive Myoclonus Epilepsies……Page 391
27. Localization-Related Epilepsies: Simple Partial Seizures, Complex Partial Seizures, and Rasmussen Syndrome……Page 401
28. Selected Disorders Associated with Epilepsy……Page 411
29. Treatment Decisions in Childhood Seizures……Page 427
30. Comparative Anticonvulsant Profile and Proposed Mechanisms of Action of Antiepileptic Drugs……Page 437
31. Evidence-Based Medicine Issues Related to Drug Selection……Page 453
32. Combination Drug Therapy: Monotherapy Versus Polytherapy……Page 465
33. Adverse Effects of Antiepileptic Drugs……Page 473
34. Status Epilepticus and Acute Seizures……Page 485
35. The Female Patient and Epilepsy……Page 501
36. Teratogenic Effects of Antiepileptic Medications……Page 513
37. Pharmacokinetic Principles of Antiepileptic Therapy in Children……Page 527
38. Dosage Form Considerations in the Treatment of Pediatric Epilepsy……Page 539
39. Principles of Drug Interactions: Implications for Treatment with Antiepileptic Drugs……Page 559
40. ACTH and Steroids……Page 569
41. Benzodiazepines……Page 581
42. Carbamazepine and Oxcarbazepine……Page 591
43. Ethosuximide, Methsuximide, and Trimethadione……Page 603
44. Felbamate……Page 609
45. Gabapentin and Pregabalin……Page 617
46. Lamotrigine……Page 627
47. Levetiracetam……Page 635
48. Barbiturates and Primidone……Page 645
49. Phenytoin and Related Drugs……Page 663
50. Sulthiame……Page 677
51. Tiagabine……Page 685
52. Topiramate……Page 695
53. Valproate……Page 709
54. Vigabatrin……Page 723
55. Vitamins, Herbs, and Other Alternative Therapies……Page 735
56. Zonisamide……Page 751
57. The Ketogenic Diet……Page 763
58. Inflammation, Epilepsy, and Anti-Inflammatory Therapies……Page 775
59. Antiepileptic Drugs in Development……Page 783
60. Surgical Evaluation……Page 795
61. Advanced Neuroimaging: PET-MRI Fusion and Diffusion Tensor Imaging……Page 809
62. Surgical Treatment of Therapy-Resistant Epilepsy in Children……Page 815
63. Outcome of Epilepsy Surgery in Childhood……Page 825
64. Vagus Nerve Stimulation Therapy in Pediatric Patients: Use and Effectiveness……Page 835
65. Economics of Pediatric Epilepsy……Page 855
66. Quality of Life in Children with Epilepsy……Page 861
67. Epilepsy, Cerebral Palsy, and IQ……Page 871
68. Academic Deficits and Interventions in Pediatric Epilepsy……Page 889
69. Cognitive Side Effects of Antiepileptic Drugs……Page 897
A……Page 907
B……Page 908
C……Page 909
E……Page 910
F……Page 911
H……Page 912
L……Page 913
M……Page 914
P……Page 915
S……Page 917
U……Page 918
Z……Page 919