Mitochondria and the Heart

José Marín-García (eds.)0-387-22824-1-254, 0-387-23187-0, 0-387-23632-5, 0-387-25574-5, 9780387255743

The function of the heart is highly dependent on oxidative energy that is generated in mitochondria. Defects in mitochondrial structure and function can be found in association with cardiovascular diseases. Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis and degradation pathways are explored. Understanding these pathways and the effects that mitochondrial defects have in cardiac pathology is extremely important in establishing the diagnosis and treatment of mitochondrial-based cardiac diseases.

José Marín-García is affiliated with The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey and the Department of Physiology & Biophysics, UMDNJ – Robert Wood Johnson Medical School, Piscataway, New Jersey.

Table of contents :
An Introduction to Mitochondria and the Heart….Pages 1-26
Mitochondrial Bioenergetics in the Heart….Pages 27-62
Heart Mitochondrial Biogenesis….Pages 63-97
ROS Generation, Antioxidants, and Cell Death….Pages 99-122
Myocardial Ischemia and Cardioprotection….Pages 123-155
Mitochondria Dysfunction in Cardiomyopathy and Heart Failure….Pages 157-196
Fatty Acid and Glucose Metabolism in Cardiac Disease….Pages 197-227
Mitochondria in Pediatric Cardiology….Pages 229-261
Mitochondria and the Aging Heart….Pages 263-287
Heart Mitochondria Signaling Pathways….Pages 289-321
Treatment of Mitochondrial-Based Cardiac Diseases. Targeting the Organelle….Pages 323-350
Future Frontiers in Mitochondrial Cardiac Biology….Pages 351-376