Target Validation in Drug Discovery

Brian W. Metcalf, Susan Dillon9780123693938, 0123693934

The sequencing of the human genome has offered a genetic description of the entire repertoire of human genes, including a subset of disease targets. Despite this knowledge, now publically available, clinical pipelines are not yet enriched in drugs derived from targets emanating from this massive sequencing effort. A major concern for researchers in the biotechnology and pharmaceutical industries is how to choose the most likely targets for drug discovery and how to validate them.Target Validation in Drug Discovery describes the background for the choice of target for several successful biological drugs (protein therapeutics). It offers excellent analyses of the underlying biology, the establishment of relative assays, and the translation to clinical trials of these drugs. Professionals in biotechnology and pharmaceutical drug discovery, clinical development, students, and academics in related areas of study will find this a unique reference for years to come.