Leptomeningeal Metastases

Neil Barshes MD, Alexis Demopoulos MD (auth.), Lauren E. Abrey M.D., Marc C. Chamberlain M.D., Herbert H. Engelhard M.D., PhD. (eds.)9780387241982, 9780387241999, 0387241981

Leptomeningeal Metastases provides the reader with an overview of the state-of-the-art therapy for the leptomeningeal patient with additional information on epidemiology, symptom management, new clinical trials, and current basic research in animal models for experimental therapies.

“Leptomeningeal metastases remains a devastating manifestation of hematologic malignancies and solid tumors. Leading figures in the field review the pathophysiology and clinical consequences of this process. State-of-the-art treatment strategies are presented highlighting advances in current management.”

Steven T. Rosen, M.D.

Series Editor

Table of contents :
Anatomy and Physiology of the Leptomeninges and CSF Space….Pages 1-16
Leptomeningeal Neoplasia: Epidemiology, Clinical Presentation, CSF Analysis and Diagnostic Imaging….Pages 17-30
Leptomeningeal Metastases from Solid Tumors (Meningeal Carcinomatosis)….Pages 31-52
Leptomeningeal Metastases from Leukemias and Lymphomas….Pages 53-69
Leptomeningeal Metastasis of Primary Central Nervous System (CNS) Neoplasms….Pages 71-85
Leptomeningeal Cancer in the Pediatric Patient….Pages 87-106
Neurosurgical Interventions for Leptomeningeal Tumor….Pages 107-119
Current Treatment of Leptomeningeal Metastases: Systemic Chemotherapy, Intrathecal Chemotherapy and Symptom Management….Pages 121-146
Radiation Therapy for Leptomeningeal Cancer….Pages 147-158
Animal Models of Leptomeningeal Cancer….Pages 159-179
Improving the Outcome of Patients with Leptomeningeal Cancer: New Clinical Trials and Experimental Therapies….Pages 181-193