Nanotechnology in Drug Delivery

Daniel P. Otto, Melgardt M. de Villiers (auth.), Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon (eds.)9780387776675, 0387776672

The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Table of contents :
Front Matter….Pages i-xiii
Front Matter….Pages 1-1
Physicochemical Principles of Nanosized Drug Delivery Systems….Pages 3-33
Block Copolymer Synthesis for Nanoscale Drug and Gene Delivery….Pages 35-67
Supercritical Fluid Technology for Nanotechnology in Drug Delivery….Pages 69-104
Nanotubes, Nanorods, Nanofibers, and Fullerenes for Nanoscale Drug Delivery….Pages 105-127
Drug Loading into and In Vitro Release from Nanosized Drug Delivery Systems….Pages 129-162
Nanotechnology-Based Biosensors in Drug Delivery….Pages 163-189
Front Matter….Pages 191-191
Nanomaterials and Biocompatibility: BioMEMS and Dendrimers….Pages 193-228
Nanomaterials and Biocompatibility: Carbon Nanotubes and Fullerenes….Pages 229-266
Factors Controlling Pharmacokinetics of Intravenously Injected Nanoparticulate Systems….Pages 267-282
Controlled Release and Nanotechnology….Pages 283-312
Nanotechnology for Intracellular Delivery and Targeting….Pages 313-346
Front Matter….Pages 347-347
Nano-sized Advanced Delivery Systems as Parenteral Formulation Strategies for Hydrophobic Anti-cancer Drugs….Pages 349-383
Engineering of Amphiphilic Block Copolymers for Drug and Gene Delivery….Pages 385-422
PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems….Pages 423-459
Nanoemulsions for Intravenous Drug Delivery….Pages 461-489
Nanotechnology for Cancer Chemotherapy….Pages 491-518
Nanotechnology for Cancer Vaccine Delivery….Pages 519-543
Stimuli-Sensitive Nanotechnology for Drug Delivery….Pages 545-578
Front Matter….Pages 579-579
Nanotechnology in Drug Delivery: Past, Present, and Future….Pages 581-596
Nanotechnology in Drug Development and Life Cycle Management….Pages 597-619
Front Matter….Pages 579-579
Nanopharmaceuticals: Challenges and Regulatory Perspective….Pages 621-646
Back Matter….Pages 647-662