Human Brain Proteome

Lisa A. Neuhold (Eds.)0-12-366863-8, 9780123668639

Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington’s disease, and Parkinson’s disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic. * Describes the latest databases and techniques for analyzing the data generated by proteomics * Outlines the latest developments in proteomic methods * Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers

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Table of contents :
Content:
Series Editor
Page ii

Contributors
Pages ix-xi

Biomarker Discovery using Molecular Profiling Approaches Original Research Article
Pages 1-30
Stephen J. Walker, Arron Xu

Proteomic Analysis of Mitochondrial Proteins Original Research Article
Pages 31-48
Mary F. Lopez, Simon Melov, Felicity Johnson, Nicole Nagulko, Eva Golenko, Scott Kuzdzal, Suzanne Ackloo, Alvydas Mikulskis

NMDA Receptors, Neural Pathways, and Protein Interaction Databases Original Research Article
Pages 49-77
Holger Husi

Dopamine Transporter Network and Pathways Original Research Article
Pages 79-96
Rajani Maiya, R.Dayne Mayfield

Proteomic Approaches in Drug Discovery and Development Original Research Article
Pages 97-126
Holly D. Soares, Stephen A. Williams, Peter J. Snyder, Feng Gao, Tom Stiger, Christian Rohlff, Athula Herath, Trey Sunderland, Karen Putnam, W.Frost White

Proteomic Informatics Original Research Article
Pages 127-157
Steven A. Russell, William Old, Katheryn A. Resing, Lawrence Hunter

Proteomics Analysis in Alzheimer’s Disease: New Insights into Mechanisms of Neurodegeneration Original Research Article
Pages 159-188
D.Allan Butterfield, Debra Boyd-Kimball

Proteomics and Alcoholism Original Research Article
Pages 189-214
Frank A. Witzmann, Wendy N. Strother

Proteomics Studies of Traumatic Brain Injury Original Research Article
Pages 215-240
Kevin K.W. Wang, Andrew Ottens, William Haskins, Ming Cheng Liu, Firas Kobeissy, Nancy Denslow, SuShing Chen, Ronald L. Hayes

Influence of Huntington’s Disease on the Human and Mouse Proteome Original Research Article
Pages 241-283
Claus Zabel, Joachim Klose

Proteomics—Application to the Brain Original Research Article
Pages 285-311
Katrin Marcus, Oliver Schmidt, Heike Schaefer, Michael Hamacher, André van Hall, Helmut E. Meyer

Index
Pages 313-323

Contents of Recent Volumes
Pages 325-337