MIG

Farber J.M.

MIG (monokine induced by I FN7) is a non-ELR CXC chemokine ligand for CXCR3. a receptor expressed primarily on T cells and NK cells. In contrast to related chemokines, MIG contains a long C-terminal extension that is subject to inactivating proteolytic processing. MIG is induced in a range of cells including macrophages, endothelial cells, and parenchymal cells, primarily in response to IFN7. MIG is a che mo tactic factor for T cells, particularly following T cell activation, and has been shown to induce adhesion of activated T cells to endothelial cells. MIG’s primary role in vivo is presumed to be in the recruitment of T cells and NK cells to inflammatory sites where IFN7 is being made. MIG has also been found to inhibit colony formation from hematopoietic progenitors in vitro and to inhibit tumor growth and angiogenesis in vivo.