Lewis Goldfrank, Neal Flomenbaum, Neal Lewin, Mary Ann Howland, Robert Hoffman, Lewis Nelson9780071360012, 0071360018)
Goldfrank’s TOXICOLOGIC EMERGENCIES, 7th Edition, delivers a goldmine of information on virtually all aspects of medical toxicology. No space is wasted-even the inside of the front and back covers provides you with essential information in easy-to-read table form. Before you’ve even turned a page, you’ll have immediate access to such valuable data as vital signs by age group, common drug and toxin-induced vital sign changes, common toxicology laboratory values and more.
And if you think the inside covers are helpful, just wait until you see what the text itself has to offer. Organized into four convenient sections, TOXICOLOGIC EMERGENCIES comprehensively covers: * General principles and techniques: how to manage the poisoned or overdosed patient, what techniques effectively eliminate toxins, which imaging studies are most useful in toxicologic emergencies, how to identify nontoxic exposures, and more * The biomedical and molecular basis of medical toxicology: how toxins affect neurotransmission, clear explanations of the principles and mathematics behind pharmacokinetics, how toxins disrupt metabolic processes, causes of metabolic alkalosis, and much more * The organ system approach to medical toxicology: how toxins affect vital signs, body temperature, blood pressure, and organs and systems throughout the body * Medical toxicology from a clinical perspective: a close-up look at more than 70 categories of toxins, featuring informative case studies as well as signs and symptoms, diagnostic testing, pathophysiology, and in-depth patient management guidelines
Table of contents :
Title……Page 2195
CONTRIBUTORS……Page 2199
TABLE OF ANTIDOTES IN DEPTH……Page 2207
PREFACE……Page 2209
ACKNOWLEDGMENTS……Page 2211
TABLE OF CONTENTS……Page 2212
1. HISTORICAL PRINCIPLES AND PERSPECTIVES……Page 1
2. TOXICOLOGIC PLAGUES AND DISASTERS IN HISTORY……Page 23
PART A. GENERAL APPROACH TO MEDICAL TOXICOLOGY……Page 36
3. PRINCIPLES OF MANAGING THE POISONED OR OVERDOSED PATIENT: AN OVERVIEW……Page 37
4. PRINCIPLES AND TECHNIQUES TO IDENTIFY THE NONTOXIC EXPOSURE……Page 40
5. TECHNIQUES USED TO PREVENT GASTROINTESTINAL ABSORPTION OF TOXIC COMPOUNDS……Page 44
6. PRINCIPLES AND TECHNIQUES APPLIED TO ENHANCE ELIMINATION OF TOXIC COMPOUNDS……Page 58
7. LABORATORY PRINCIPLES AND TECHNIQUES FOR EVALUATION OF THE POISONED OR OVERDOSED PATIENT……Page 69
8. DIAGNOSTIC IMAGING IN TOXICOLOGY……Page 94
9. ELECTROCARDIOGRAPHIC PRINCIPLES……Page 119
PART B. THE BIOCHEMICAL AND MOLECULAR BASIS OF MEDICAL TOXICOLOGY……Page 131
10. NEUROTRANSMITTERS……Page 133
11. PHARMACOKINETIC AND TOXICOKINETIC PRINCIPLES……Page 166
12. CHEMICAL PRINCIPLES……Page 186
13. BIOCHEMICAL PRINCIPLES……Page 202
14. HEPATIC PRINCIPLES……Page 216
15. IMMUNOLOGIC PRINCIPLES……Page 231
16. MUTAGENS, CARCINOGENS AND TERATOGENS……Page 244
PART C. THE PATHOPHYSIOLOGIC BASIS OF MEDICAL TOXICOLOGY: THE ORGAN SYSTEM APPROACH……Page 253
17. VITAL SIGNS AND TOXIC SYNDROMES……Page 255
18. THERMOREGULATORY PRINCIPLES……Page 261
19. NEUROLOGIC PRINCIPLES……Page 282
20. RESPIRATORY PRINCIPLES……Page 303
21. CARDIOVASCULAR PRINCIPLES……Page 315
22. GASTROINTESTINAL PRINCIPLES……Page 335
23. RENAL PRINCIPLES……Page 346
24. FLUID, ELECTROLYTE & ACID-BASE PRINCIPLES……Page 364
25. HEMATOLOGIC PRINCIPLES……Page 381
26. ENDOCRINE PRINCIPLES……Page 398
27. OPHTHALMIC PRINCIPLES……Page 411
28. OTOLARYNGOLOGIC PRINCIPLES……Page 420
29. DERMATOLOGIC PRINCIPLES……Page 432
30. GENITOURINARY PRINCIPLES……Page 441
PART D. THE CLINICAL BASIS OF MEDICAL TOXICOLOGY. SECTION I. CASE STUDIES IN TOXICOLOGIC EMERGENCIES……Page 455
31. MANAGING THE SYMPTOMATIC PATIENTWITH A POSSIBLE TOXIC EXPOSURE……Page 457
32. ACETAMINOPHEN……Page 480
33. SALICYLATES……Page 507
34. NONSTEROIDAL ANTIINFLAMMATORY AGENTS……Page 528
35. ANTIHISTAMINES AND DECONGESTANTS……Page 535
36. IRON……Page 548
37. VITAMINS……Page 563
38. DIETING AGENTS AND REGIMENS……Page 571
39. METHYLXANTHINES……Page 578
40. ANTIDIABETIC AND HYPOGLYCEMIC AGENTS……Page 593
41. ANTICONVULSANTS……Page 614
42. ANTICOAGULANTS……Page 631
43. ANTITUBERCULOUS AGENTS……Page 655
44. ANTIMALARIAL AGENTS……Page 671
45. ANTIMIGRAINE AGENTS……Page 681
46. ANTIBIOTICS……Page 689
47. ANTINEOPLASTIC AGENTS……Page 705
48. CARDIAC GLYCOSIDES……Page 724
49. b-ADRENERGIC ANTAGONISTS……Page 741
50. CALCIUM CHANNEL BLOCKERS……Page 762
51. MISCELLANEOUS ANTIHYPERTENSIVES……Page 775
52. ANTIDYSRHYTHMIC AGENTS……Page 787
53. INHALATIONAL ANESTHETICS……Page 799
54. NEUROMUSCULAR BLOCKING AGENTS……Page 806
55. LOCAL ANESTHETICS……Page 824
56. PHARMACEUTICAL ADDITIVES……Page 835
57. CYCLIC ANTIDEPRESSANTS……Page 847
58. SEROTONIN REUPTAKE INHIBITORS AND ATYPICAL ANTIDEPRESSANTS……Page 865
59. ANTIPSYCHOTICS……Page 875
60. MONOAMINE OXIDASE INHIBITORS……Page 885
61. LITHIUM……Page 894
62. OPIOIDS……Page 901
63. SEDATIVE-HYPNOTIC AGENTS……Page 929
64. ETHANOL……Page 952
65. DISULFIRAM AND DISULFIRAMLIKE REACTIONS……Page 971
66. TOXIC ALCOHOLS……Page 980
67. COCAINE……Page 1004
68. AMPHETAMINES……Page 1020
69. PHENCYCLIDINE AND KETAMINE……Page 1034
70. LYSERGIC ACID DIETHYLAMIDE AND OTHER HALLUCINOGENS……Page 1046
71. MARIJUANA……Page 1054
72. SUBSTANCEWITHDRAWAL……Page 1059
73. NICOTINE AND TOBACCO PREPARATIONS……Page 1075
74. FOOD POISONING……Page 1085
75. BOTULISM……Page 1100
76. MUSHROOMS……Page 1115
77. HERBAL PREPARATIONS……Page 1129
78. PLANTS……Page 1150
79. ARSENIC……Page 1183
80. LEAD……Page 1200
81. MERCURY……Page 1239
82. METALS……Page 1249
82A BISMUTH……Page 1250
82B CADMIUM……Page 1254
82C COPPER……Page 1262
83. THALLIUM……Page 1272
84. ANTISEPTICS, DISINFECTANTS, AND STERILANTS……Page 1281
85. CAMPHOR AND MOTH REPELLENTS……Page 1295
86. HYDROCARBONS……Page 1303
87. CAUSTICS AND BATTERIES……Page 1323
88. INSECTICIDES: ORGANIC PHOSPHORUS COMPOUNDS AND CARBAMATES……Page 1346
89. INSECTICIDES: ORGANOCHLORINES, PYRETHRINS, DEET……Page 1366
90. RODENTICIDES……Page 1379
91. HERBICIDES……Page 1393
92. INDUSTRIAL POISONING: INFORMATION AND CONTROL……Page 1411
93. HAZMAT INCIDENT RESPONSE WITH PRE- AND INTERHOSPITAL CARE OF THE POISONED PATIENT……Page 1421
94. METHEMOGLOBINEMIA……Page 1438
95. SIMPLE ASPHYXIANTS AND PULMONARY IRRITANTS……Page 1453
96. SMOKE INHALATION……Page 1469
97. CARBON MONOXIDE……Page 1478
98. CYANIDE AND HYDROGEN SULFIDE……Page 1498
99. RADIATION……Page 1515
100. CHEMICAL AND BIOLOGICWEAPONS……Page 1527
101. SNAKES AND OTHER REPTILES……Page 1552
102. ARTHROPODS……Page 1573
103. MARINE ENVENOMATIONS……Page 1592
104. USE OF THE INTENSIVE CARE UNIT FOR POISONED PATIENTS……Page 1598
105. REPRODUCTIVE AND PERINATAL PRINCIPLES……Page 1606
106. PEDIATRIC PRINCIPLES……Page 1629
107. GERIATRIC PRINCIPLES……Page 1640
108. THE HIV-POSITIVE PATIENT-AIDS PHARMACOLOGY AND TOXICOLOGY……Page 1647
109. SUBSTANCE USERS……Page 1666
110. HEALTHCAREWORKERS……Page 1677
111. FARM TOXICOLOGY……Page 1690
112. SPORTS TOXICOLOGY……Page 1699
113. PSYCHOSOCIAL PRINCIPLES IN ASSESSMENT AND INTERVENTION……Page 1713
114. PSYCHIATRIC PRINCIPLES……Page 1720
115. NURSING PRINCIPLES……Page 1731
116. POISON INFORMATION CENTERS AND POISON EPIDEMIOLOGY……Page 1747
117. ADVERSE DRUG EVENTS……Page 1753
118. RISK MANAGEMENT AND LEGAL PRINCIPLES……Page 1768
119. POSTMORTEM TOXICOLOGY……Page 1781
120. PRINCIPLES OF EPIDEMIOLOGY AND RESEARCH DESIGN……Page 1789
CASE STUDIES FROM THE……Page 1799
ANSWERS TO CASE STUDY QUESTIONS……Page 1809
STUDY QUESTIONS……Page 1847
ANSWERS……Page 1969
INDEX……Page 2081
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