Environmental Stressors in Health and Disease

Jürgen Fuchs9780824705305, 0824705300

A range of medical and biological sciences, including occupational health and pharmacology are represented by the contributors. They review issues of molecular and cellular biology as well as clinical aspects of environmental oxidants and their effects on target organs. After looking at the basic pathology induced by pro-oxidant environmental xenobiotic they consider lungs, skin, and eyes as target organs of environmental oxidants. Among specific topics are the role of oxidative stress in chemical carcinogenesis, cigarette smoking and pulmonary oxidative damage, ozone stress in the skin barrier, and the role of ocular free radicals in age-related macular degeneration.

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Table of contents :
Series Introduction……Page 4
Preface……Page 8
Contents……Page 10
Contributors……Page 14
1
Free Radical Reactions In Human Disease……Page 18
2
Radicals And Inflammation Mediators And Modulators……Page 34
3
Autoimmunity Caused By Oxidizing Foreign Compounds……Page 70
4
Role Of Oxidative Stress In Chemical Carcinogenesis……Page 98
5
Proposed Mechanisms Of Arsenic Toxicity Carcinogenesis……Page 120
6
Redox Regulation Of Gene Expression And Transcription Factors In Response To Environmental Oxidants……Page 132
7
Cigarette Smoking And Pulmonary Oxidative Damage……Page 152
8
Health Effects Of Diesel Exhaust And Diesel Exhaust Particles……Page 174
9
The Role Of Free Radicals In AsbestosAnd Silica-induced Fibrotic Lung Diseases……Page 202
10
Reactive Oxygen Species And Silica-induced Carcinogenesis……Page 220
11
Atmospheric Oxidants And Respiratory Tract Surfaces……Page 242
12
Redox Modulation And Oxidative Stress In Dermatotoxicology……Page 254
13
Dermatotoxicology Of Environmental And Occupational Chemical Hazards: Agents And Action……Page 288
14
Photooxidative Stress In Skin And Regulation Of Gene Expression……Page 336
15
Ozone Stress In The Skin Barrier……Page 352
16
Immunotoxicity Of Environmental Agents In The Skin……Page 362
17
Environmental Stressors And The Eye……Page 382
18
Free Radicals And Aging Of Anterior Segment Tissues Of The Eye……Page 398
19
The Role Of Ocular Free Radicals In Age-related Macular Degeneration……Page 440
20
Nutritional Influence On Risk For Cataract……Page 474
Index……Page 506