Essentials of apoptosis: a guide for basic and clinical research

Stefan J. Riedl, Fiona L. Scott (auth.), Zheng Dong, Xiao-Ming Yin (eds.)9781603273817, 1603273816

As a fundamental biological process, cell death and cell survival is essential to the normal homeostasis of the organism. Our knowledge on this process has been tremendously expanded in the past two decades. Essentials of Apoptosis: A Guide for Basic and Clinical Research was first published in 2003. It timely provided a comprehensive but concise summary of the essential information of apoptosis to both new investigators to the field and seasoned researchers seeking an integrated view of the topics. The past several years have witnessed significant new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. Notable progresses have been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive crosstalk with works in other fields. The second edition incorporates these new developments, in addition to the basic core concepts and machinery of apoptosis. Multiple new topics are added that expand the coverage on different types of cell death (apoptosis, necrosis, autophagic death and mitotic death), and on different death pathways (mediated by mitochondria, endoplasmic reticulum, death receptors, or lysosome). Furthermore, several integrated topics linking cell death to metabolism, redox status, transcription regulation are included and a systems biology approach to study apoptosis is introduced. Moreover, the roles of apoptosis and cell death in the pathogenesis of many human diseases in every major organ system are explored in details with novel therapeutic outlooks. This edition is the result of the hard work by more than 80 leading experts from across the world.

Authoritative, comprehensive and highly instructive, the second edition of Essentials of Apoptosis should be valuable for both novice and seasoned investigators, as an informative reference as well as a practical guide.

Table of contents :
Front Matter….Pages i-xxvi
Front Matter….Pages 1-1
Caspases: Activation, Regulation, and Function….Pages 3-24
The Bcl-2 Family Proteins….Pages 25-61
The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis….Pages 63-93
Structural Biology of Programmed Cell Death….Pages 95-118
The Death Receptor Pathway….Pages 119-150
The Mitochondrial Pathway: Focus on Shape Changes….Pages 151-175
The Endoplasmic Reticulum Pathway….Pages 177-197
Reactive Oxygen Species in Cell Fate Decisions….Pages 199-221
The Integration of Metabolism and Cell Death….Pages 223-237
Transcriptional Regulation of Apoptosis….Pages 239-260
Clearance of Apoptotic Cells – Mechanisms and Consequences….Pages 261-282
Systems Biology Approaches to the Study of Apoptosis….Pages 283-297
Front Matter….Pages 299-299
Programmed Cell Death in Plants: Apoptotic but Not Quite….Pages 301-324
Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae ….Pages 325-354
Programmed Cell Death in C. elegans ….Pages 355-373
Cell Death in Drosophila ….Pages 375-405
Front Matter….Pages 407-407
Cell Death: Defining and Misshaping Mammalian Embryos….Pages 409-422
Matters of Life and Death in the Immune System….Pages 423-442
Cell Death in the Hematopoietic System….Pages 443-459
Cell Death in Acute Neuronal Injury….Pages 461-478
Front Matter….Pages 407-407
Apoptosis in Neurodegenerative Diseases….Pages 479-504
Apoptosis in Cardiovascular Pathogenesis….Pages 505-521
Apoptosis in Lung Injury and Disease….Pages 523-545
Apoptosis in Liver Injury and Liver Diseases….Pages 547-564
Apoptosis in Acute Kidney Injury….Pages 565-579
Apoptosis in Cancer Biology and Cancer Therapeutics….Pages 581-596
Front Matter….Pages 597-597
Necrosis: Molecular Mechanisms and Physiological Roles….Pages 599-633
Caspase-Independent Mitotic Death….Pages 635-646
Lysosomal Proteases in Cell Death….Pages 647-669
Autophagy and Cell Death….Pages 671-688
Front Matter….Pages 689-689
Analysis of Apoptosis: Basic Principles and Protocols….Pages 691-711
Back Matter….Pages 713-742