Exploiting Chemical Diversity for Drug Discovery

P A Bartlett, M Entzeroth0-85404-842-1, 978-0-85404-842-7

Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays, this book provides a comprehensive overview of modern approaches to lead identification.

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Table of contents :
BK9780854048427-FP001.pdf……Page 1
BK9780854048427-FP005.pdf……Page 5
BK9780854048427-FP009.pdf……Page 9
BK9780854048427-FP011.pdf……Page 11
BK9780854048427-00001.pdf……Page 23
BK9780854048427-00033.pdf……Page 55
BK9780854048427-00055.pdf……Page 77
BK9780854048427-00091.pdf……Page 113
BK9780854048427-00112.pdf……Page 134
BK9780854048427-00137.pdf……Page 159
BK9780854048427-00161.pdf……Page 183
BK9780854048427-00184.pdf……Page 206
BK9780854048427-00201.pdf……Page 223
BK9780854048427-00233.pdf……Page 255
BK9780854048427-00247.pdf……Page 269
BK9780854048427-00263.pdf……Page 285
BK9780854048427-00291.pdf……Page 313
BK9780854048427-00313.pdf……Page 335
BK9780854048427-00336.pdf……Page 358
BK9780854048427-00364.pdf……Page 386
BK9780854048427-00386.pdf……Page 408
BK9780854048427-00405.pdf……Page 427