Samter’s Immunologic Diseases

Austen

The thoroughly updated Sixth Edition of this classic two-volume work continues to provide a comprehensive overview of immunology, its clinical applications, immunopathology, and allergy. A text revised and updated throughout facilitates an understanding of the host mechanisms in immunologic diseases. The strength of this text is its clinically oriented emphasis on immunologic diseases and differential approach to symptoms and syndromes. This edition features an increased clinical coverage and is an essential reference for all clinical immunologists, rheumatologists, and allergists.

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Table of contents :
Samter’s Immunologic Diseases……Page 2
PREFACE……Page 17
1 INNATE IMMUNITY: LINKAGES TO ADAPTIVE RESPONSES……Page 18
2 ARCHITECTURE OF THE IMMUNE SYSTEM……Page 25
3 MAJOR HISTOCOMPATIBILITY GENE COMPLEX: STRUCTURE AND FUNCTION……Page 34
5 T-CELL BIOLOGY AND THE THYMUS……Page 48
4 T-CELL ANTIGEN RECEPTORS……Page 39
6 ANTIGEN PROCESSING AND PRESENTATION……Page 56
7 IMMUNOGENICITY AND ANTIGENICITY……Page 64
8 LYMPHOCYTE SIGNALING……Page 76
9 T-LYMPHOCYTE ACTIVATION, COSTIMULATION, AND TOLERANCE: SIGNALS, MECHANISMS, AND CLINICAL APPLICATIONS……Page 84
10 CYTOKINES AND TYPE 1 IMMUNITY……Page 92
11 CYTOKINE REGULATION OF TYPE 2 IMMUNITY……Page 98
12 APOPTOSIS AND THE IMMUNE RESPONSE……Page 109
13 ANTIBODIES AND THEIR RECEPTORS……Page 117
14 BIOLOGY OF B CELLS……Page 124
15 ADHESION MOLECULES……Page 131
16 CHEMOKINES AND CHEMOKINE RECEPTORS……Page 139
17 HEMATOPOIETIC CYTOKINES……Page 146
18 T-LYMPHOCYTE EFFECTOR ACTIVITY……Page 159
19 NATURAL KILLER CELLS……Page 166
20 NEUTROPHILS……Page 169
21 MONOCYTES AND MACROPHAGES……Page 177
22 EOSINOPHILS……Page 187
23 BASOPHILS……Page 194
24 BIOLOGY OF THE MAST CELL……Page 200
25 IMMUNE COMPLEXES……Page 212
26 COMPLEMENT SYSTEM……Page 221
27 ARACHIDONIC ACID PATHWAYS……Page 235
28 PRIMARY IMMUNODEFICIENCIES OF LYMPHOCYTES……Page 246
29 PHAGOCYTE DISORDERS……Page 255
30 COMPLEMENT IN DISEASE: INHERITED AND ACQUIRED COMPLEMENT DEFICIENCIES……Page 269
31 LYMPHOCYTIC LYMPHOMAS AND HODGKIN’S DISEASE……Page 277
32 MULTIPLE MYELOMA……Page 292
33 MACROGLOBULINEMIA……Page 301
34 AMYLOIDOSIS……Page 308
35 EOSINOPHILIA……Page 317
36 MASTOCYTOSIS……Page 323
37 RHEUMATOID ARTHRITIS……Page 328
38 JUVENILE RHEUMATOID ARTHRITIS……Page 354
39 SYSTEMIC LUPUS ERYTHEMATOSUS……Page 364
40 SJÖGREN’S SYNDROME……Page 380
41 SYSTEMIC SCLEROSIS (SCLERODERMA)……Page 388
42 IDIOPATHIC INFLAMMATORY MYOPATHIES: DERMATOMYOSITIS, POLYMYOSITIS, AND RELATED DISORDERS……Page 399
43 THE SPONDYLOARTHROPATHIES……Page 406
44 RHEUMATIC FEVER AND OTHER CARDIOVASCULAR DISEASE Samter’s Immunologic Diseases……Page 418
45 VASCULITIS……Page 429
46 ANTIPHOSPHOLIPID SYNDROME……Page 438
47 SARCOIDOSIS……Page 445
48 DIABETES MELLITUS……Page 451
49 AUTOIMMUNE THYROID DISEASE, ADDISON DISEASE, AND AUTOIMMUNE POLYGLANDULAR SYNDROMES……Page 465
50 IMMUNOLOGIC RENAL DISEASE……Page 481
51 MYASTHENIA GRAVIS……Page 497
52 AUTOIMMUNE BLISTERING MUCOCUTANEOUS DISEASES……Page 508
53 IMMUNE FUNCTION IN OCULAR INFLAMMATORY DISEASE……Page 514
54 AUTOIMMUNE HEPATOBILIARY DISEASES……Page 521
55 IMMUNOLOGIC DISEASES OF THE GASTROINTESTINAL TRACT……Page 531
56 MULTIPLE SCLEROSIS……Page 543
57 AUTOIMMUNE HEMOLYTIC ANEMIA……Page 561
58 IMMUNE THROMBOCYTOPENIA……Page 570
59 BLOOD GROUPS, IMMUNOLOGIC HAZARDS OF TRANSFUSION, AND HEMOLYTIC DISEASE OF THE NEWBORN……Page 577
60 IMMUNOLOGIC ASPECTS OF FERTILITY AND INFERTILITY……Page 587
61 ALLERGENS……Page 598
62 GENETICS OF ALLERGIC DISEASE……Page 613
63 ALLERGIC DISEASES……Page 619
64 ANAPHYLACTIC SYNDROME……Page 625
65 ASTHMA……Page 633
66 URTICARIA AND ANGIOEDEMA: PATHOGENESIS, ASSESSMENT, AND TREATMENT……Page 653
67 ATOPIC DERMATITIS……Page 662
68 ALLERGIC REACTIONS TO FOODS……Page 672
69 INSECT VENOM ALLERGY……Page 678
70 IMMUNOLOGIC LUNG DISEASE……Page 683
71 ALLERGIC CONTACT DERMATITIS……Page 692
72 ALLERGIC REACTIONS TO DRUGS……Page 696
73 NATURAL RUBBER LATEX ALLERGY……Page 707
74 HUMAN IMMUNODEFICIENCY VIRUS INFECTION……Page 712
75 EPSTEIN-BARR VIRUS……Page 731
76 TUBERCULOSIS AND LEPROSY……Page 742
77 CRYOPATHIES: CRYOGLOBULINS AND CRYOFIBRINOGENEMIA……Page 753
78 VIRUSES……Page 767
79 LYME DISEASE……Page 779
80 PARASITIC DISEASES……Page 786
81 THE IMMUNOCOMPROMISED HOST……Page 798
82 AGING AND THE IMMUNE SYSTEM……Page 812
83 HEMATOPOIETIC STEM CELL TRANSPLANTATION……Page 818
84 TISSUE AND SOLID ORGAN ALLOGRAFT REJECTION……Page 837
85 IMMUNOLOGY OF XENOTRANSPLANTATION……Page 845
86 CALCINEURIN AS A THERAPEUTIC TARGET……Page 856
87 T-CELL ANTIGEN AND COSTIMULATORY RECEPTORS AS THERAPEUTIC TARGETS……Page 862
88 CYTOKINES AND CANCER IMMUNOTHERAPY……Page 876
89 ANTI-TNF-a THERAPHY IN RHEUMATOID ARTHRITIS AND OTHER DISEASES……Page 880
90 The Use of Intravenous Immunoglobulin……Page 889
91 MONOCLONAL ANTIBODY THERAPY……Page 895
92 DRUGS THAT MODULATE THE IMMUNE RESPONSE……Page 905
93 NEW APPROACHES TO VACCINE DEVELOPMENT……Page 912
Volume 1 Color Figures……Page 915
Volume 2 Color Figures……Page 919