A. Rich (auth.), Professor Dr. Volker Erdmann, Prof. Dr. hab. Jan Barciszewski, Professor Dr. Jürgen Brosius (eds.)9783540272618, 3540272615
Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.
Table of contents :
Why RNA and DNA Have Different Structures….Pages 1-8
Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria….Pages 9-43
Regulatory RNAs in Mammals….Pages 45-72
Aminoglycoside Interactions with RNAs and Nucleases….Pages 73-96
High-Throughput RNA Interference in Functional Genomics….Pages 97-104
Antiviral Applications of RNAi….Pages 105-116
RNA Interference: Its Use as Antiviral Therapy….Pages 117-150
Gene Silencing of Virus Replication by RNA Interference….Pages 151-171
Progress in the Development of Nucleic Acid Therapeutics….Pages 173-196
Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries….Pages 197-221
Ribozymes and siRNAs: From Structure to Preclinical Applications….Pages 223-242
Strategies to Identify Potential Therapeutic Target Sites in RNA….Pages 243-259
Oligonucleotide-Based Antiviral Strategies….Pages 261-287
Gene-Expressed RNA as a Therapeutic: Issues to Consider, Using Ribozymes and Small Hairpin RNA as Specific Examples….Pages 289-303
RNA Aptamers: From Basic Science Towards Therapy….Pages 305-326
RNA Aptamers Directed Against Oligosaccharides….Pages 327-340
Aptamer-Based Biosensors: Biomedical Applications….Pages 341-357
Application of Aptamers in Therapeutics and for Small-Molecule Detection….Pages 359-373
RNA Aptamers as Potential Pharmaceuticals Against Infections with African Trypanosomes….Pages 375-393
RNA Targeting Using Peptide Nucleic Acid….Pages 395-403
Locked Nucleic Acid: High-Affinity Targeting of Complementary RNA for RNomics….Pages 405-422
Engineering RNA-Based Circuits….Pages 423-445
Selection of RNase-Resistant RNAs….Pages 447-455
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