The Management of Sickle Cell Disease

The fourth edition of The Management of Sickle Cell Disease – developed by physicians, nurses, psychologists, and social workers who specialize in the care of children and adults with sickle cell disease – describes the current approach to counseling and also to management of many of the medical complications of sickle cell disease. It is organized into four parts: Diagnosis and Counseling, Health Maintenance, Treatment of Acute and Chronic Complications, and Special Topics. Multiple new therapies are now available for children and adults with sickle cell disease, and often the options to be chosen present a dilemma for both patients and physicians. This book does not provide answers to many of these newer questions but rather explains the choices available. It is to serve as an adjunct to recent textbooks that delve more deeply into all aspects of the disorder. NIH Publication.

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Table of contents :
CONTENTS……Page 5
PREFACE……Page 7
CONTRIBUTORS……Page 9
INTRODUCTION……Page 17
DIAGNOSIS AND COUNSELING……Page 19
WORLD WIDE WEB RESOURCES……Page 21
Neonatal Screening……Page 23
Sickle Cell Trait……Page 31
Genetic Counseling……Page 35
HEALTH MAINTENANCE……Page 39
Child Health Care Maintenance……Page 41
ADOLESCENT HEALTH CARE AND TRANSITIONS……Page 51
ADULT HEALTH CARE MAINTENANCE……Page 57
COORDINATION OF CARE: ROLE OF MID-LEVEL PRACTITIONERS……Page 63
PSYCHOSOCIAL MANAGEMENT……Page 69
TREATMENT OF ACUTE AND CHRONIC COMPLICATIONS……Page 73
PAIN……Page 75
INFECTION……Page 91
TRANSIENT RED CELL APLASIA……Page 97
STROKE AND CENTRAL NERVOUS SYSTEM DISEASE……Page 99
SICKLE CELL EYE DISEASE……Page 111
CARDIOVASCULAR MANIFESTATIONS……Page 115
ACUTE CHEST SYNDROME AND OTHER PULMONARY COMPLICATIONS……Page 119
GALL BLADDER AND LIVER……Page 127
SPLENIC SEQUESTRATION……Page 135
RENAL ABNORMALITIES IN SICKLE CELL DISEASE……Page 139
PRIAPISM……Page 145
BONES AND JOINTS……Page 149
LEG ULCERS……Page 155
SPECIAL TOPICS……Page 159
CONTRACEPTION AND PREGNANCY……Page 161
ANESTHESIA AND SURGERY……Page 165
TRANSFUSION, IRON OVERLOAD, AND CHELATION……Page 169
FETAL HEMOGLOBIN INDUCTION……Page 177
HEMATOPOIETIC CELL TRANSPLANTATION……Page 183
GENETIC MODULATION OF PHENOTYPE BY EPISTATIC GENES……Page 189
HIGHLIGHTS FROM FEDERALLY FUNDED STUDIES……Page 197