A Biologist’s Guide to Analysis of DNA Microarray Data

Steen Knudsen9780471224907, 0-471-22490-1

Microarrays are low-density arrays of DNA molecules that permit many hybridization experiments to be performed in parallel. A Biologist’s Guide to Analysis of DNA Microarray Data is the first authoritative text to focus on analysis (as opposed to technology) in diverse biological and medical applications of microarrays.Written for biologists without special training in data analysis and statistics, the Guide takes over where the image analysis software that accompanies DNA array equipment typically leaves off-with a file of signal intensities and fold changes compared to a control. The broad spectrum of established analysis approaches is covered, including cluster analysis, function prediction, and principal component analysis. A thorough, critical review of software programs is presented, and criteria for selecting programs are discussed. Each chapter contains a Further Reading section categorized by topic as well as a summary, and highlights numerous real examples to illustrate the key concepts. Chapter topics include:Basic data analysisVisualization by reduction of dimensionalityCluster analysis of expression dataMolecular classifiersGenotyping chipsSoftware issues and data formatsA Biologist’s Guide to Analysis of DNA Microarray Data meets the needs of research professionals, students, and trainees alike for a compact yet thorough guide to analyzing microarray data.