Peptidomimetics Protocols

Free Download

Authors:

Edition: 1

Series: Methods in Molecular Medicine

ISBN: 9780896035171, 0896035174

Size: 28 MB (29305082 bytes)

Pages: 538/538

File format:

Language:

Publishing Year:

Category:

Wieslaw M. Kazmierski9780896035171, 0896035174

A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive “warheads,” applicable in enzyme inhibitors, are also disclosed.

Reviews

There are no reviews yet.

Be the first to review “Peptidomimetics Protocols”
Shopping Cart
Scroll to Top