Exodus-1/LARC/MIP-З alfa (SCYA 20)

Hromas R.

Exodus-1/LARC/MIP-Заlfa (SCYA 20) is a recently discovered CC (or beta) chemokine. It is only distantly related to other CC chemokines. representing a unique structure among the family. With such a unique structure, it is not surprising that it has a unique function. It mediates chemotaxis of naive dendritic cells and memory T cells via its receptor, CCR6. beta-Defensins have also been shown to stimulate chemotaxis through CCR6. thereby linking innate and acquired immunity to sites of local inflammation. Exodus-1, LARC, MIP-За has also been shown to inhibit the proliferation of normal and leukemic hematopoietic progenitors.