Directed Molecular Evolution of Proteins

Brakmann S. (ed.), Johnson K. (ed.)3-527-29799-5

Fourteen chapters provide a snapshot of some of the recent advances in the application of evolutionary and combinatorial techniques in the development of proteins. After outlining the fundamental principles of the field, papers address such topics as the directed evolution of binding proteins by cell surface display, screening strategies of biocatalyst discovery, directed evolution as a means to create enantioselective enzymes for use in organic chemistry, and applied molecular evolution of enzymes involved in synthesis and repair of DNA.