Genetics of Colorectal Cancer

John D. Potter MD, PhD, David Hunter (auth.), John D. Potter MD, PhD, Noralane M. Lindor MD (eds.)0387095675, 9780387095684, 9780387095677, 9783540095675, 3540095675, 0387095683

The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, MYH-Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. Genetics of Colorectal Cancer provides the most up-to-date information in each of these areas.

Table of contents :
Front Matter….Pages i-xi
Colorectal Cancer: Epidemiology….Pages 5-25
Mouse Models of Intestinal Cancer….Pages 27-49
The Chromosomal-Instability Pathway and APC Gene Mutation in Colorectal Cancer….Pages 53-72
DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis….Pages 73-95
Pathways and Pathology….Pages 97-121
Familial Adenomatous Polyposis….Pages 125-139
DNA Mismatch Repair and Lynch Syndrome….Pages 141-169
Additional Syndromes with Hereditary Predisposition to Colorectal Cancer….Pages 173-181
Familial Colorectal Cancer Type X….Pages 183-186
Families with Serrated Neoplasia of the Colon….Pages 187-191
Peutz–Jeghers Syndrome….Pages 193-198
Juvenile Polyposis….Pages 199-205
BLM Mutation and Colorectal Cancer Susceptibility….Pages 207-212
The Role of p53 in Colorectal Cancer….Pages 213-217
Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer….Pages 219-220
Genetic Variability in Folate-Mediated One-Carbon Metabolism and Risk of Colorectal Neoplasia….Pages 223-242
Genetic Variability in NSAID Targets and NSAID-Metabolizing Enzymes and Colorectal Neoplasia….Pages 243-260
The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer….Pages 261-276
Calcium and Vitamin D….Pages 277-298
Back Matter….Pages 299-309