Supercritical Fluid Chromatography with Packed Columns

Klaus Anton, Claire Berger9780824700133, 0824700139

Providing an original praxis-oriented overview of packed column supercritical fluid chromatography (pSFC) from the analytical to industrial preparative scale, this timely reference discusses and evaluates established applications and techniques, new and promising developments, and commercial instrumentation devices for use in industry as well as reveals possibilities for problem solving and future innovations. Highlights the uses of pSFC in the pharmaceutical industry as an orthogonal technique to high-performance liquid chromatography (HPLC) and a timesaving method for analyzing and formulating drug substances and products! Covering basic principles and a host of diverse applications that meet industrial needs and standards, Supercritical Fluid Chromatography with Packed Columns emphasizes the importance of selecting the right equipment prior to developing applications shows how evaporative light-scattering detection can solve the problem of analyzing compounds with low UV absorption considers packed capillary columns as a means of expanding pSFC frontiers towards capillary SFC reviews in detail chiral packed subcritical fluid chromatography (SubFC) and SFC illustrates the utilization of supercritical fluids in sample preparation and chromatographic analysis emphasizes economical and ecological parameters in the breakthrough of industrial preparative scale chromatography and much more! In addition, this unique volume is packed with useful features, such as an up-to-date compound index – facilitating maximum accessibility to chemical compounds already analyzed with pSFC a subject index – containing all important keywords in the field of pSFC numerous unpublished results a current bibliography for pSFC separation of chiral compounds and over 50 commonly used polymer additives nearly 350 tables, equations, drawings, and photographs – including more than 150 chromatograms