Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

Patrick Augustijns, Patrick Augustijns; Marcus Brewster0387691499, 978-0-387-69149-7, 978-0-387-69154-1, 0387691545

Table of contents :
front-matter……Page 1
1-Principles of Solubility……Page 9
2.Ionic Equilibria and the pH Dependence of Solubility……Page 36
3.Solvent Systems for Crystallization and Polymorph Selection……Page 59
4.Solubility Issues in Early Discovery and HTS……Page 116
5.Practical Aspects of Solubility Determination in Pharmaceutical Preformulation……Page 142
6.Biorelevant Dissolution Media……Page 155
7…….Page 182
8.The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines……Page 224
9…….Page 260
10.Solubilizing Systems for Parenteral Formulation Development—Small Molecules……Page 312
11.Aqueous Solubilizing Systems for Parenteral Formulation Development—Proteins……Page 343
12…….Page 360
13.Pharmaceutical Solvents as Vehicles for Topical Dosage Forms……Page 404
14.Pharmaceutical Solvents for Pulmonary Drug Delivery……Page 428
back-matter……Page 443