Molecular Aspects of Innate and Adaptive Immunity

Kenneth B. M. Reid, Robert B. Sim0854046984, 9780854046980

This book provides a survey of topics, in the area of innate and adaptive immunity, which have been researched within the MRC Immunochemistry Unit, at Oxford University, over a period of forty years. The topics include: antibody structure, for which the first Director of the Immunochemistry Unit, Professor R.R. Porter, was awarded a Nobel prize in 1972; the characterization of membrane proteins on lymphoid cells, leading to the concept of these molecules belonging to an immunoglobulin super family; the proteins of the human serum complement system, one of the body’s major defenses against microbial infection; the human cell, surface integrins and the hyaluronan-binding proteins, which are involved in regulation of inflammation at cell surfaces and within the extracellular matrix; the family of collecting molecules, containing distinct globular carbohydrate-binding domains linked to collagen-like regions, which play important roles in innate immunity in the lungs and bloodstream by immediate recognition and clearance of microbial pathogens.

Each chapter in the book gives a brief historical background to a topic and then provides a survey of recent advances in the field and is written by internationally recognized renowned experts. The theme running through the chapters is that of protein structure-function relationships, including, amongst others, descriptions of quaternary structures of large oligomeric proteins, of Factor H and C1q binding to specific ligands, and of the chemistry of the mechanism of catalysis of covalent binding of activated C3 and C4 proteins to nucleophilic groups on microbial surfaces. In several chapters excellent descriptions are given with respect to how the immune system can be recruited to combat microbial infection via proteins of both the innate and adaptive immune systems.

The book also includes notable chapters which are excellent examples of the importance of how the isolation, characterization, protein engineering and crystallization has resulted in a full understanding of complex protein-protein interactions involved in the recognition and triggering events of important sections of the immune system: Structure and Function of the C1 Complex, Gerard J. Arlaud; Chemical Engineering of Therapeutic Antibodies, George T. Stevenson; Leukocyte surface proteins: purification and characterization, A. Neil Barclay; Cell Surface Integrins, Suet-Mien Tan and S.K. Alex Law.