Zinc Finger Proteins : From Atomic Contact to Cellular Function

Shiro Iuchi, Natalie Kuldell0306482290, 9780306482298, 9781417574476

Table of contents :
Cover Page……Page 1
Inside Cover……Page 3
Copyright © 2005……Page 4
Contents……Page 5
Editors and Contributors……Page 7
Preface……Page 13
Abbreviations……Page 14
CHAPTER 1 – The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account……Page 17
CHAPTER 2 – C2H2 Zinc Fingers As DNA Binding Domains……Page 23
CHAPTER 3 – TFIIIA: A Sophisticated Zinc Finger Protein……Page 30
CHAPTER 4 – GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction……Page 36
CHAPTER 5 – The DNA-Binding Domain of GATA Transcription Factors—A Prototypical Type IV Cys2-Cys2 Zinc Finger……Page 42
CHAPTER 6 – MutM: Single C2C2 Zinc Finger-DNA Interaction……Page 47
CHAPTER 7 – Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function……Page 51
CHAPTER 8 – Zinc Finger Interactions with Metals and Other Small Molecules……Page 55
CHAPTER 9 – Synthetic Zinc Finger Transcription Factors……Page 63
CHAPTER 10 – TFIIIA and p43: Binding to 5S Ribosomal RNA……Page 72
CHAPTER 11 – RNA Binding by Single Zinc Fingers……Page 82
CHAPTER 12 – Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA……Page 92
CHAPTER 13 – Tandem CCCH Zinc Finger Proteins in mRNA Binding……Page 96
CHAPTER 14 – Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a……Page 107
CHAPTER 15 – LIM Domain and Its Binding to Target Proteins……Page 115
CHAPTER 16 – RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation……Page 122
CHAPTER 17 – Structure and Function of the CBP/p300 TAZ Domains……Page 130
CHAPTER 18 – A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2……Page 137
CHAPTER 19 – The FYVE Finger: A Phosphoinositide Binding Domain……Page 144
CHAPTER 20 – The BTB Domain Zinc Finger Proteins……Page 150
CHAPTER 21 – KRAB Zinc Finger Proteins: A Family of Repressors Mediating Heterochromatin-Associated Gene Silencing……Page 167
CHAPTER 22 – The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors……Page 172
CHAPTER 23 – Sp1 and Huntington’s Disease……Page 184
CHAPTER 24 – The Role of WT1 in Development and Disease……Page 190
CHAPTER 25 – Yin Yang 1……Page 198
CHAPTER 26 – The Multiple Cellular Functions of TFIIIA……Page 211
CHAPTER 27 – The Role of the Ikaros Gene Family in Lymphocyte Development……Page 216
CHAPTER 28 – Basonuclin: A Zinc Finger Protein of Epithelial Cells and Reproductive Germ Cells……Page 223
CHAPTER 29 – ZAS Zinc Finger Proteins: The Other κB-Binding Protein Family……Page 229
CHAPTER 30 – Role of GATA Factors in Development……Page 237
CHAPTER 31 – The Androgen Receptor and Spinal and Bulbar Muscular Atrophy……Page 248
CHAPTER 32 – The Role of XPA in DNA Repair……Page 255
CHAPTER 33 – MOF, an Acetyl Transferase Involved in Dosage Compensation in Drosophila, Uses a CCHC Finger for Substrate Recognition……Page 263
CHAPTER 34 – MDM2: RING Finger Protein and Regulator of p53……Page 268
CHAPTER 35 – The Zip Family of Zinc Transporters……Page 277
CHAPTER 36 – Apoptosis by Zinc Deficiency……Page 281
INDEX……Page 288
Back Cover……Page 292