Integrated Drug Discovery Technologies

Houng-Yau Mei, Anthony W. Czarnik9780824706494, 0-8247-0649-8

Rubicon Genomics, Inc., Ann Arbor, MI. Reference provides a global overview of emerging drug discovery technologies. Presents new techniques from the disciplines of chemistry, biology, and computational sciences. Explains the rationale and developmental background behind evolving practices and highlights the impact of information technology on drug discovery.

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Table of contents :
Preface……Page 4
Contents……Page 6
Contributors……Page 10
The Motivation: A Top-Down View……Page 14
Target Identification and Validation: Coupling Genotype to Phenotype……Page 32
Functional Genomics……Page 70
Integrated Proteomics Technologies……Page 92
Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications……Page 130
SNP Scoring for Drug Discovery Applications……Page 162
Protein Display Chips……Page 180
Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets……Page 204
High-Throughput Screening as a Discovery Resource……Page 234
Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS+plus): Multiple Read-Out Options for Miniaturized Screening……Page 260
Homogeneous Time-Resolved Fluorescence……Page 276
ADME-Tox Screening in Drug Discovery……Page 302
Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells……Page 332
Miniaturization Technologies for High-Throughput Biology……Page 354
Data Management for High-Throughput Screening……Page 378
Combinatorial Chemistry: The History and the Basics……Page 408
New Synthetic Methodologies……Page 420
Supports for Solid-Phase Synthesis……Page 476
The NMR “Toolkit” for Compound Characterization……Page 498
Materials Management……Page 556
Index……Page 568