In Vivo Models of Inflammation

Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan3-7643-7519-1, 3-7643-7520-5, 978-3-7643-7519-5, 3764377577, 9783764377571, 9783764377601, 3764377607

Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. The aim of this second edition is to act as a complement to the first by describing and updating the standard models that are most utilized for specific disease areas. In addition, this 2nd edition includes new models exploring emerging areas of inflammation research.

It provides detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response.

New approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has also been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells.

The book provides the scientist with an up-to-date reference manual for selecting the best animal model for their specific question. Chapters describing current regulations in the United States, United Kingdom, and Japan are also included.

---

Table of contents :
Volume I……Page 5
List of contributors……Page 7
Preface to the first edition……Page 10
Preface to the second edition……Page 11
Rat models of arthritis: Similarities, differences, advantages, and disadvantages in the identification of novel therapeutics……Page 12
Murine collagen induced arthritis……Page 46
Use of animal models of osteoarthritis in the evaluation of potential new therapeutic agents……Page 75
Models of inflammatory processes in cancer……Page 93
Advances in stem cell research: use of stem cells in animal models of muscular dystrophy……Page 113
Gene transfer technology……Page 134
Transgenics……Page 147
Nanotechnology: Towards the detection and treatment of inflammatory diseases……Page 163
UK legislation of in vivo aspects in inflammation research……Page 185
Japanese guidelines and regulations for scientific and ethical animal experimentation……Page 195
United States guidelines and regulations in animal experimentation……Page 200
C……Page 210
I……Page 211
N……Page 212
S……Page 213
W……Page 214