Group B Coxsackieviruses

E. Domingo, V. Martin, C. Perales, C. Escarmis (auth.), Steven Tracy, Dr. M. Steven Oberste, Dr. Kristen M. Drescher (eds.)3-540-00154-9, 3-540-00210-3, 3-540-00534X, 3-540-00844-6

This monograph reviews information published since 1997 on the group B coxsackieviruses (CVB), a large and important group of human enteroviruses. The CVB were discovered in the mid-20th century, during the search for other poliovirus types, and within a very few years of this discovery, the CVB had been implicated as causes of human myocarditis and pancreatitis. The study of the CVB is still inextricably linked with the fate of their well-known relatives, the polioviruses, for as poliovirus eradication proceeds around the world, the CVB emerge more prominently as the enteroviruses best suited for continuing studies in enteroviral molecular biology as well as understanding the mechanisms underlying enteroviral pathogenesis. This volume reviews and presents modern views on the spectrum of CVB biologies, from interaction of the virus with its receptor through replication, speciation, and induction of disease.

Table of contents :
Front Matter….Pages i-xix
Coxsackieviruses and Quasispecies Theory: Evolution of Enteroviruses….Pages 3-32
Comparative Genomics of the Coxsackie B Viruses and Related Enteroviruses….Pages 33-47
Group B Coxsackievirus Virulence….Pages 49-63
The Coxsackievirus and Adenovirus Receptor….Pages 67-87
Coxsackievirus B RNA Replication: Lessons from Poliovirus….Pages 89-121
CVB Translation: Lessons from the Polioviruses….Pages 123-147
Preferential Coxsackievirus Replication in Proliferating/Activated Cells: Implications for Virus Tropism, Persistence, and Pathogenesis….Pages 149-173
The Impact of CVB3 Infection on Host Cell Biology….Pages 177-198
Host Immune Responses to Coxsackievirus B3….Pages 199-221
Pediatric Group B Coxsackievirus Infections….Pages 223-239
CVB-Induced Pancreatitis and Alterations in Gene Expression….Pages 241-258
The CVB and Etiology of Type 1 Diabetes….Pages 259-274
Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy….Pages 275-292
Autoimmunity in Coxsackievirus Infection….Pages 293-314
CVB Infection and Mechanisms of Viral Cardiomyopathy….Pages 315-335
Back Matter….Pages 337-340