Genomic signal processing and statistics

Edward R. Dougherty; Ilya Shmulevich; Jie Chen; Z. Jane Wang9789775945075, 9775945070

Recent advances in genomic studies have stimulated synergetic research and development in many cross-disciplinary areas. Genomic data, especially the recent large-scale microarray gene expression data, represents enormous challenges for signal processing and statistics in processing these vast data to reveal the complex biological functionality. This perspective naturally leads to a new field, genomic signal processing (GSP), which studies the processing of genomic signals by integrating the theory of signal processing and statistics. Written by an international, interdisciplinary team of authors, this invaluable edited volume is accessible to students just entering this emergent field, and to researchers, both in academia and industry, in the fields of molecular biology, engineering, statistics, and signal processing. The book provides tutorial-level overviews and addresses the specific needs of genomic signal processing students and researchers as a reference ! book The book aims to address current genomic challenges by exploiting potential synergies between genomics, signal processing, and statistics, with special emphasis on signal processing and statistical tools for structural and functional understanding of genomic data. The book is partitioned into three parts. In part I, a brief history of genomic research and a background introduction from both biological and signal-processing/statistical perspectives are provided so that readers can easily follow the material presented in the rest of the book. In part II, overviews of state-of-the-art techniques are provided. We start with a chapter on sequence analysis, and follow with chapters on feature selection, clustering, and classification of microarray data. The next three chapters discuss the modeling, analysis, and simulation of biological regulatory networks, especially gene regulatory networks based on Boolean and Bayesian approaches. The next two chapters treat visualization and c! ompression of gene data, and supercomputer implementation of genomic signal processing systems. Part II concludes with two chapters on systems biology and medical implications of genomic research. Finally, part III discusses the future trends in genomic signal processing and statistics research.