W.E. Crusio and R.T. Gerlai (Eds.)0444502394, 9780444502391
Table of contents :
Content:
Preface. Behavioral neurogenetics: the new synthesis
Pages vii-x
Wim E. Crusio, Robert T. Gerlai
Acknowledgements
Pages xi-xii
List of contributors
Pages xiii-xix
Chapter 1.1 The multi-dimensional database requirements of brain information in the era of rapid gene identification Original Research Article
Pages 3-19
Floyd E. Bloom, Warren G. Young
Chapter 1.2 Bioinformatics and neuroscience in the post-genomic era Original Research Article
Pages 20-30
Bruno W.S. Sobral, Michael M. Harpold
Chapter 1.3 PsycheMap — An online database of psychiatric genetics linkage, association, and genome mapping projects Original Research Article
Pages 31-39
Nigel M. Williams, Iain Fenton, Michael J. Owen
Chapter 1.4 Experimental design and statistical inference Original Research Article
Pages 40-57
Douglas Wahlsten
Chapter 2.1.1 Mapping single locus mutations in mice: towards gene identification of neurological traits Original Research Article
Pages 61-81
Wayne N. Frankel, Benjamin A. Taylor
Chapter 2.1.2 Experimental strategies for quantitative trait loci (QTL) analysis in laboratory animals Original Research Article
Pages 82-99
David A. Blizard, Ariel Darvasi
Chapter 2.1.3 Linkage strategies for mapping genes for complex traits in man Original Research Article
Pages 100-112
Laura Almasy, John Blangero
Chapter 2.1.4 Genetic association studies in behavioral neuroscience Original Research Article
Pages 113-121
Philip Gorwood
Chapter 2.1.5 DNA pooling in allelic association studies Original Research Article
Pages 122-131
Nigel M. Williams, Michael J. Owen
Chapter 2.1.6 Research strategies for the analysis of neurological mutants of the mouse Original Research Article
Pages 132-146
Constantino Sotelo, Jean Mariani
Chapter 2.1.7 Genetic dissection of mouse behavior using induced mutagenesis Original Research Article
Pages 147-165
Lawrence H. Pinto, Joseph S. Takahashi
Chapter 2.1.8 Mutagenesis in zebra fish: studying the brain dopamine systems Original Research Article
Pages 166-176
Su Guo, Wolfgang Driever, Arnon Rosenthal
Chapter 2.1.9 Behavioral and electrophysiological screens for isolating zebra fish mutants with visual system defects Original Research Article
Pages 177-186
John E. Dowling
Chapter 2.2.1 Subtractive cDNA hybridization and brain: then, now and tomorrow Original Research Article
Pages 189-199
Joseph B. Watson
Chapter 2.2.2 Applying differential display to brain research Original Research Article
Pages 200-211
Iaudio V. Mello, Erich D. Jarvis
Chapter 2.2.3 Brain region-specific genes: the hippocampus Original Research Article
Pages 212-224
Benjamin S. Pickard, Ben J. Davies, Ken A. Rose, Genevieve Stapleton, Muriel Steel, Richard Lathe
Chapter 2.2.4 Application of real-time RT-PCR for quantification of gene expression Original Research Article
Pages 225-236
Jane Winer, Natasha Shinsky, Robert Gerlai, P. Mickey Williams
Chapter 2.2.5 Analyzing genomic DNA discordance between monozygotic twins Original Research Article
Pages 237-256
J. Bouchard, C. Foulon, N. Storm, G.H. Nguyen, C.L. Smith
Chapter 3.1.1 Embryonic stem cells and gene targeting Original Research Article
Pages 259-271
Anthony Wynshaw-Boris, Lisa Garrett, Amy Chen, Carrolee Barlow
Chapter 3.1.2 Generation of transgenic mice by pronuclear DNA injection Original Research Article
Pages 272-281
Anthony Wynshaw-Boris, Lisa Garrett, Amy Chen, Carrolee Barlow
Chapter 3.1.3 Brain region-specific and temporally restricted gene knockout using the Cre recombinase system Original Research Article
Pages 282-290
Joe Z. Tsien
Chapter 3.1.4 Regulated temporal and spatial expression of mutants of CaMKII and calcineurin with the tetracycline-controlled transactivator (tTA) and reverse tTA (rtTA) systems Original Research Article
Pages 291-304
Isabelle M. Mansuy, Mark Mayford, Eric R. Kandel
Chapter 3.1.5 The use of targeted point mutants in the study of learning and memory Original Research Article
Pages 305-314
Karl Peter Giese
Chapter 3.1.6 Genetic dissection of a postsynaptic multiprotein complex controlling synaptic plasticity and learning in the mouse Original Research Article
Pages 315-328
Seth G.N. Grant
Chapter 3.1.7 Molecular genetic analysis of glutamate receptor function in long-term potentiation in the mouse hippocampus Original Research Article
Pages 329-340
Zhengping Jia, You Ming Lu, Nadia Agopyan, John Roder
Chapter 3.1.8 Targeting aggression in mice Original Research Article
Pages 341-351
Randy J. Nelson, Lance J. Kriegsfeld
Chapter 3.1.9 Behavioral analysis of Dvl1-deficient mice reveals a role for the Dvl1 gene in social behaviors and sensorimotor gating Original Research Article
Pages 352-363
Richard Paylor, Nardos Lijam, Michael P. McDonald, Jacqueline N. Crawley, Daniel J. Sussman, Anthony Wynshaw-Boris
Chapter 3.1.10 Targeting genes associated with mammalian behavior: past mistakes and future solutions Original Research Article
Pages 364-375
Robert Gerlai
Chapter 3.2.1 Gene transfer and therapy in the CNS Original Research Article
Pages 379-395
Marie-Claude Senut, Steven T. Suhr, Fred H. Gage
Chapter 3.2.2 Adenovirus vectors for gene transfer into the central nervous system Original Research Article
Pages 396-414
Martine Barkats, Olga Corti, Jacques Mallet
Chapter 3.2.3 Regulatable adenoviral technology in behavioural neuroscience Original Research Article
Pages 415-424
E. Clea Warburton, Brad Geddes, Thomas Harding, James B. Uney
Chapter 3.2.4 Antisense oligonucleotides to selectively suppress gene expression in the brain Original Research Article
Pages 425-437
Giuseppe Pollio, Adriana Maggi
Chapter 3.2.5 Application of recombinant proteins, peptides and antibodies in exploring the role of Src in regulating synaptic function Original Research Article
Pages 438-454
Michael W. Salter
Chapter 3.2.6 The use of immunoadhesins in neurobiology Original Research Article
Pages 455-464
David L. Shelton
Chapter 3.2.7 Protein targeting in the functional analysis of EphA receptors: the use of immunoadhesins Original Research Article
Pages 465-484
R. Gerlai, N. Shinsky, A. Shih, P. Williams, J. Winer, M. Armanini, P. Moran, B. Cairns, J. Winslow, W.-Q. Gao, H.S. Phillips
Chapter 3.3.1 A novel approach to Drosophila neurophysiology” the targeted expression of aequorin Original Research Article
Pages 487-495
Philippe Rosay, Kim Kaiser, J. Douglas Armstrong
Chapter 3.3.2 Behavior-genetic and molecular analysis of naturally occurring variation in Drosophila larval foraging behavior Original Research Article
Pages 496-511
Marla B. Sokolowski, Craig A.L. Riedl
Chapter 3.3.3 Structure-function analysis of the Drosophila optic lobes Original Research Article
Pages 512-536
Gert O. Pflugfelder
Chapter 3.3.4 Testing associative learning in Drosophila Original Research Article
Pages 537-550
Thomas Préat
Chapter 3.3.5 Caenorhabditis elegans and the genetics of learning Original Research Article
Pages 551-568
Kevin R. Peters, Jennifer A. Galloway, Catharine H. Rankin
Chapter 3.3.6 Forward genetic approaches in the analysis of Caenorhabditis elegans Original Research Article
Pages 569-584
Anne C. Hart
Chapter 3.3.7 Analyzing neuropeptide function in Caenorhabditis elegans by reverse genetics Original Research Article
Pages 585-601
Chris Li
Chapter 4.1 Ethological approaches in behavioral neurogenetic research Original Research Article
Pages 605-613
Robert Gerlai
Chapter 4.2 What animals remember about past events: an ethological approach Original Research Article
Pages 614-626
Nicola S. Clayton
Chapter 4.3 Motor performance of spontaneous murine mutations with cerebellar atrophy Original Research Article
Pages 627-637
R. Lalonde, C. Strazielle
Chapter 4.4 Methodological considerations for testing learning in mice Original Research Article
Pages 638-651
Wim E. Crusio
Chapter 4.5 Drug and alcohol dependence-related behaviors Original Research Article
Pages 652-666
John C. Crabbe, Christopher L. Cunningham
Chapter 4.6 Evaluating anxiety in rodents Original Research Article
Pages 667-673
Jacqueline N. Crawley
Chapter 4.7 A neurobehavioral system approach in rats to study the molecular biology of fear Original Research Article
Pages 674-695
Jeffrey B. Rosen, Seema Malkani, Karin J. Wallace, Barbara L. Thompson
Chapter 4.8 Measuring aggression in the mouse Original Research Article
Pages 696-709
Pierre L. Roubertoux, Isabelle Le Roy, Stephane Mortaud, Fernando Perez-Diaz, Sylvie Tordjman
Chapter 4.9 Methodological issues in the assessment of behavioral development in laboratory mice Original Research Article
Pages 710-721
P.E. Wainwright
Chapter 4.10 Understanding maternal behavior: analyses of behavior, c-Fos expression and calmodulin binding proteins in the medial preoptic area and other areas of the rat brain Original Research Article
Pages 722-737
Alison S. Fleming, Danton H. O’Day
Chapter 4.11 Measuring rodent exploratory behavior Original Research Article
Pages 738-749
Catherine Belzung
Chapter 5.1 sychiatric genetics current perspective Original Research Article
Pages 753-772
Douglas F. Levinson
Chapter 5.2 Defining phenotypes for psychiatric genetics Original Research Article
Pages 773-782
Marika Nosten-Bertrand, Frank Bellivier, Marion Leboyer
Chapter 5.3 Trinucleotide repeat disorders Original Research Article
Pages 783-804
Gunnar Sandberg, Kerstin Lindblad, Ben A. Oostra, Martin Schalling
CHAPTER 5.4 Finding liability genes for schizophrenia Original Research Article
Pages 805-819
Nick J.O. Jacobsen, Nigel M. Williams, Michael J. Owen
CHAPTER 5.5 Genetics of idiopathic epilepsy Original Research Article
Pages 820-840
Louise Bate, Mark Gardiner
CHAPTER 5.6 Identification and functional analysis of genes and genetic risk factors in Alzheimer’s disease Original Research Article
Pages 841-862
Chris De Jonghe, Christine Van Broeckhoven
Chapter 5.7 Aging, Alzheimer’s disease and frameshift mutations Original Research Article
Pages 863-879
Wilhelmina H. Van den Hurk, Fred W. Van Leeuwen, Gerard J.M. Martens
Chapter 5.8 Transgenic mouse models of Alzheimer’s disease Original Research Article
Pages 880-894
Karen Duff
Chapter 5.9 Modelling Down syndrome in mice Original Research Article
Pages 895-913
Mara Dierssen, Melanie Pritchard, Cristina Fillat, Mariona Arbonés, Josep M. Aran, Jesfls Flórez, Estivill Xavier
Chapter 6.1 Genes and human behavior: scientific and ethicalimplications of the human genome project Original Research Article
Pages 917-926
Jon Beckwith
Chapter 6.2 Ethical issues and psychiatric genetics Original Research Article
Pages 927-935
A.E. Farmer, P. McGuffin
Chapter 6.3 Ethical implications of knock-out and transgenesistechniques for animal research Original Research Article
Pages 936-948
Louis Marie Houdebine
Subject Index
Pages 949-965
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