Bone metastases: a translational and clinical approach

Vassiliki Tzelepi, Athanassios C. Tsamandas, Vassiliki Zolota, Chrisoula D. Scopa (auth.), Dr. Dimitrios Kardamakis MD, PhD, DMRT, Dr. Vassilios Vassiliou MD, PhD, Dr. Edward Chow MBBS, PhD, FRCPC (eds.)9781402098185, 1402098189, 9781402098192

“Bone Metastases: A Translational and Clinical Approach” serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume:
describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases.
This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease.

Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Table of contents :
Front Matter….Pages I-XVI
Front Matter….Pages 1-1
Bone Anatomy, Physiology and Function….Pages 3-30
Pathophysiology of Bone Metastases….Pages 31-50
Angiogenesis and Bone Metastasis: Implications for Diagnosis, Prevention and Treatment….Pages 51-76
Natural History, Prognosis, Clinical Features and Complications of Metastatic Bone Disease….Pages 77-92
Bone Biomarkers in Research and Clinical Practice….Pages 93-116
Front Matter….Pages 117-117
Radiologic Evaluation Of Skeletal Metastases: Role Of Plain Radiographs And Computed Tomography….Pages 119-136
The Contribution Of Nuclear Medicine In The Diagnosis Of Bone Metastases….Pages 137-162
Magnetic Resonance Imaging Of Metastatic Bone Disease….Pages 163-181
Front Matter….Pages 183-183
Radiotherapy And Bone Metastases….Pages 185-193
Biphosphonates In The Management Of Metastatic Bone Disease….Pages 195-231
Combined Radiotherapy and Bisphosphonates: State of Art….Pages 233-250
Biphosphonates in the Treatment of Bone Metastases – Osteonecrosis of the Jaw….Pages 251-262
Surgical Management of Bone Metastases….Pages 263-286
The Role of Chemotherapy in the Treatment of Bone Metastases….Pages 287-298
Hormonotherapy of Bone Metastases….Pages 299-320
Radionuclide Therapy….Pages 321-341
Front Matter….Pages 343-343
Assessment of Therapeutic Response….Pages 345-370
Outcome Measures in Bone Metastases Clinical Trials….Pages 371-394
Back Matter….Pages 395-400