Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach

Mario Grassi, Gabriele Grassi, Romano Lapasin, Italo Colombo9780849330872, 0849330874

Developing realistic and reliable models of drug release requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, this book builds a firm understanding of all elements needed to conceive, build, and implement successful models of drug release. The authors begin by introducing the basics of modeling, relevant physiology, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as drug solubility dependence on drug crystal size. From this baseline, they explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes.